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ATM antibody (AA 2870-3056)
ATM
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-ATM Antibody
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Target
See all ATM Antibodies
ATM
(Ataxia Telangiectasia Mutated (ATM))
Binding Specificity
All epitopes for ATM antibodies
AA 2870-3056
Reactivity
All reactivities for ATM antibodies
Human
Host
All hosts for ATM antibodies
Rabbit
Clonality
All clonalities for ATM antibodies
Polyclonal
Conjugate
All conjugates for ATM antibodies
This ATM antibody is un-conjugated
Application
All applications for ATM antibodies
Western Blotting (WB)
Purification
Antigen affinity
Immunogen
Human partial recombinant protein (AA 2870-3056) was used as the immunogen for this ATM antibody.
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Titration of the ATM antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
Restrictions
For Research Use only
Handling
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Buffer
0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
Storage
-20 °C
Storage Comment
The lyophilized ATM antibody can be stored at 4°C to -20°C. After reconstitution, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Target Details for ATM
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Target
ATM
(Ataxia Telangiectasia Mutated (ATM))
Alternative Name
ATM (ATM Products )
Synonyms
ATM antibody, Atm antibody, CG6535 antibody, Dmel\\CG6535 antibody, Tefu antibody, atm antibody, atm/tefu antibody, dATM antibody, tef antibody, Xatm antibody, at1 antibody, atdc antibody, tel1 antibody, telo1 antibody, AT1 antibody, ATA antibody, ATC antibody, ATD antibody, ATDC antibody, ATE antibody, TEL1 antibody, TELO1 antibody, AI256621 antibody, C030026E19Rik antibody, telomere fusion antibody, ATM serine/threonine kinase L homeolog antibody, ATM serine/threonine kinase antibody, ataxia telangiectasia mutated antibody, ataxia telangiectasia mutated (atm) antibody, serine/threonine-protein kinase ATM antibody, tefu antibody, atm.L antibody, atm antibody, ATM antibody, EDI_100660 antibody, CpipJ_CPIJ001772 antibody, BDBG_08252 antibody, PAAG_02532 antibody, MCYG_05088 antibody, VDBG_06833 antibody, ACLA_015700 antibody, LOC5565620 antibody, MGYG_07634 antibody, PGTG_14279 antibody, Atm antibody
Background
Ataxia telangiectasia mutated, also known as TEL1 or TELO1, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. The ATM protein is a member of the phosphatidylinositol 3-kinase family of proteins that respond to DNA damage by phosphorylating key substrates involved in DNA repair and/or cell cycle control. The gene is mapped to chromosome 11q22.3. ATM has an essential role in the reconstitutive capacity of hematopoietic stem cells but is not as important for the proliferation or differentiation of progenitors in a telomere-independent manner. It functions directly in the repair of chromosomal DNA double-stranded breaks by maintaining DNA ends in repair complexes generated during lymphocyte gene assembly.
Gene ID
472
Pathways
p53 Signaling , Apoptosis , DNA Damage Repair , Inositol Metabolic Process , Positive Regulation of Response to DNA Damage Stimulus
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