CYP11B1 antibody (C-Term)

Catalog No. ABIN3030679

Product Details anti-CYP11B1 Antibody

Target: CYP11B1 (Cytochrome P450, Family 11, Subfamily B, Polypeptide 1 (CYP11B1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP11B1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human CYP11B1 (RNFYHVPFGFGMRQC) was used as the immunogen for this CYP11B1 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the CYP11B1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the CYP11B1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for CYP11B1

Target: CYP11B1 (Cytochrome P450, Family 11, Subfamily B, Polypeptide 1 (CYP11B1))

Alternative Name: CYP11B1 (CYP11B1 Products)

Synonyms: CPN1 antibody, CYP11B antibody, FHI antibody, P450C11 antibody, AA389061 antibody, Cyp11b antibody, Cyp11b-1 antibody, Cp11ba antibody, RATCP11BA antibody, P450c11 antibody, cytochrome P450, family 11, subfamily B, polypeptide 1 antibody, cytochrome P450 family 11 subfamily B member 1 antibody, cytochrome P450, family 11, subfamily b, polypeptide 1 antibody, cytochrome P450, subfamily XI B, polypeptide 1 antibody, CYP11B1 antibody, Cyp11b1 antibody

Background: Cytochrome p450, family 11, subfamily B, polypeptide 1, also called Steroid 11-beta-hydroxylase or P450C11, is a steroid hydroxylase found in the zona fasciculata. The gene functions primarily in mitochondria in the zona fasciculata of the adrenal cortex to convert 11-deoxycortisol to cortisol and 11-deoxycorticosterone to corticosterone. CYP11B1 is a member of the cytochrome P450 superfamily of enzymes. mRNA is present in human cardiac tissue samples from left and right atria, aorta, apex, intraventricular septum, and atrioventricular node, as well as whole adult and fetal heart. Ventricles did not express CYP11B1. In patients with 11-beta-hydroxylase deficiency leading to hypertension and congenital adrenal hyperplasia, Pascoe et al. identified mutations in the CYP11B1 gene.

UniProt: P15538

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones, C21-Steroid Hormone Metabolic Process, Carbohydrate Homeostasis