c-MYC antibody

Catalog No. ABIN306633

The Mouse Monoclonal anti-c-MYC antibody (Clone 33) (ABIN306633) specifically detects c-MYC in WB, IHC and IP. The antibody is reactive with Human, Mouse and Avian samples.

Quick Overview for c-MYC antibody (ABIN306633)

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Reactivity: Human, Mouse, Avian

Host: Mouse

Clonality: Monoclonal

Conjugate: This c-MYC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Clone: 33

Product Details anti-c-MYC Antibody

Purpose: Mouse anti Human myc

Characteristics: Human c-myc belongs to a family of 5 myc oncogenes. Amplification of c-myc has been found in several types of human tumors including breast and colon carcinomas. Induction of c-myc in cells grown in the appropriate growth factors or co-expression with survival genes, such as bcl-2 causes cell proliferation. In the abscence of these factors, c-myc expression causes cell death. c-myc gene gives rise to at least two nuclear phosphoproteins of 64 kDa and 67 kDa, the unphosphorylated form is 49 kDa.

Purification: Protein A/G Chromatography

Isotype: IgG1

Application Details

Application Notes: Application: Western Blot, Immunoprecipitation (both with and without SDS), Immunofluorescence on frozen sections (c-Myc is a labile protein, therefore preotease inhibitors should be used at all times).

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for c-MYC

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Alternative Name: c-myc

Background: Cmyc, Myc proto-oncogene protein, transcription factor p64

Molecular Weight: 64kDa,67kDa,49kDa

UniProt: P01106, P01108, P09416

Pathways: p53 Signaling, Cell Division Cycle, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effect