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PLK1 antibody (pSer482, pSer486, pSer490)
PLK1
Reactivity: Xenopus laevis
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-PLK1 Antibody
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Target
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PLK1
(Polo-Like Kinase 1 (PLK1))
Binding Specificity
All epitopes for PLK1 antibodies
pSer482, pSer486, pSer490
Reactivity
All reactivities for PLK1 antibodies
Xenopus laevis
Host
All hosts for PLK1 antibodies
Rabbit
Clonality
All clonalities for PLK1 antibodies
Polyclonal
Conjugate
All conjugates for PLK1 antibodies
This PLK1 antibody is un-conjugated
Application
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Western Blotting (WB)
Specificity
Specific for the ~120k PLKK protein phosphorylated at Ser482,486,490.
Cross-Reactivity
Xenopus laevis
Predicted Reactivity
rat, mouse human, zebra fish
Purification
Antigen Affinity Purified from Pooled Serum
Immunogen
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser482/486/490 conjugated to KLH
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Alternatives
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Application Details
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Application Notes
Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
100 μL in 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
Storage
-20 °C
Target Details for PLK1
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Target
PLK1
(Polo-Like Kinase 1 (PLK1))
Alternative Name
PLK1 (PLK1 Products )
Synonyms
PLK antibody, STPK13 antibody, plk antibody, PLK-1 antibody, Plx1 antibody, stpk13 antibody, Plk antibody, cb525 antibody, cb636 antibody, ik:tdsubc_2d1 antibody, wu:fb37g11 antibody, wu:fb76g03 antibody, xx:tdsubc_2d1 antibody, polo like kinase 1 antibody, polo like kinase 1 S homeolog antibody, polo-like kinase 1 antibody, polo-like kinase 1 (Drosophila) antibody, Serine/threonine-protein kinase plk-1 antibody, PLK1 antibody, plk1.S antibody, plk1 antibody, Plk1 antibody, plk-1 antibody
Background
Considerable evidence indicates that a polo-like kinase (PLK) plays an important role in cell cycle regulation. PLK is also required for bipolar spindle formation, activation of the anaphase-promoting complex/cyclosome, and cytokinesis. Recent work led to the identification of a PLKK that is thought to be responsible for activation of PLK. Recent work (Erikson, et al., 2004) has shown that PLKK is in turn activated by phosphorylation at three sites (Ser482, Ser486 and Ser490). Thus activation of PLK is thought to involve a kinase cascade involving the phosphorylation of Ser482,486,490 in PLKK.
Molecular Weight
'120 kDa
Gene ID
380481
UniProt
P70032
Pathways
Cell Division Cycle , M Phase
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