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VEGFR2/CD309 antibody (pTyr1175)
VEGFR2
Reactivity: Human, Mouse, Rat
IHC, IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-VEGFR2/CD309 Antibody
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Target
See all VEGFR2/CD309 (VEGFR2) Antibodies
VEGFR2/CD309 (VEGFR2)
(VEGF Receptor 2 (VEGFR2))
Binding Specificity
All epitopes for VEGFR2/CD309 antibodies
pTyr1175
Reactivity
All reactivities for VEGFR2/CD309 antibodies
Human, Mouse, Rat
Host
All hosts for VEGFR2/CD309 antibodies
Rabbit
Clonality
All clonalities for VEGFR2/CD309 antibodies
Polyclonal
Conjugate
All conjugates for VEGFR2/CD309 antibodies
This VEGFR2/CD309 antibody is un-conjugated
Application
All applications for VEGFR2/CD309 antibodies
Immunohistochemistry (IHC), Immunofluorescence (IF)
Specificity
The Antibody detects endogenous level of VEGFR2 only when phosphorylated at tyrosine 1175.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
Immunogen
Peptide sequence around phosphorylation site of pTyr1175 (K-D-Y (p) -I-V) derived from Human VEGFR2. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Immunohistochemistry: 1:50-1:100 Immunofluorescence: 1:100-1:200
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Target Details for VEGFR2/CD309
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Target
VEGFR2/CD309 (VEGFR2)
(VEGF Receptor 2 (VEGFR2))
Alternative Name
VEGFR2 (VEGFR2 Products )
Synonyms
CD309 antibody, FLK1 antibody, VEGFR antibody, VEGFR2 antibody, 6130401C07 antibody, Flk-1 antibody, Flk1 antibody, Krd-1 antibody, Ly73 antibody, VEGFR-2 antibody, sVEGFR-2 antibody, Vegfr-2 antibody, FLK-1 antibody, flk-1 antibody, vegfr-2 antibody, KDR antibody, FLK/KDR antibody, flk1 antibody, flk1b antibody, kdrb antibody, si:busm1-205d10.1 antibody, si:ch211-254j6.1 antibody, si:ch211-278f21.4 antibody, wu:fc31a09 antibody, fk52c05 antibody, flk antibody, kdr antibody, kdra antibody, vegfr2 antibody, vegfr4 antibody, vegr2 antibody, wu:fk52c05 antibody, kinase insert domain receptor antibody, kinase insert domain protein receptor antibody, vascular endothelial growth factor receptor kdr-like antibody, kinase insert domain receptor (a type III receptor tyrosine kinase) antibody, kinase insert domain receptor like antibody, KDR antibody, Kdr antibody, LOC100136647 antibody, kdr antibody, kdrl antibody
Background
Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions
Molecular Weight
230 kDa
NCBI Accession
NP_002244
UniProt
P35968
Pathways
RTK Signaling , Glycosaminoglycan Metabolic Process , Signaling Events mediated by VEGFR1 and VEGFR2 , Growth Factor Binding , Regulation of long-term Neuronal Synaptic Plasticity , VEGF Signaling
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