Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogen
This PPP3CC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 482-512 amino acids from the C-terminal region of human PPP3CC.
CALNA3 antibody, CNA3 antibody, PP2Bgamma antibody, Calnc antibody, ppp3cc antibody, sb:cb767 antibody, si:dkey-21k4.5 antibody, calna3 antibody, cna3 antibody, pp2bgamma antibody, im:7163784 antibody, zgc:158685 antibody, protein phosphatase 3 catalytic subunit gamma antibody, protein phosphatase 3, catalytic subunit, gamma isoform antibody, protein phosphatase 3, catalytic subunit, gamma isozyme, a antibody, protein phosphatase 3, catalytic subunit, gamma isozyme antibody, protein phosphatase 3, catalytic subunit, gamma isozyme L homeolog antibody, protein phosphatase 3, catalytic subunit, gamma isozyme, b antibody, PPP3CC antibody, Ppp3cc antibody, ppp3cca antibody, ppp3cc antibody, ppp3cc.L antibody, ppp3ccb antibody
Background
Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha, calcineurin A-beta, and calcineurin A-gamma, have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95 % amino acid identity).