CD46 antibody
-
- Target See all CD46 Antibodies
- CD46
-
Reactivity
- Human
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- This CD46 antibody is un-conjugated
-
Application
- Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificity
- Reacts with human 44 kDa CD46 protein
- Cross-Reactivity (Details)
- Diffuse and duplicated bands can be seen due to the glycosylation of CD46.
- Purification
- Purified (protein A)
- Immunogen
- Recombinant CD46 protein
- Clone
- 3F1
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product CD46 Primary Antibody
-
-
- Application Notes
-
Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ELISA1:20 000 - 1:100 000 IHC-P10 μg/mL WB1:2000 - 1:10000 - Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Must be reconstituted in distilled water.
- Concentration
- 1 mg/mL
- Buffer
- PBS
- Storage
- 4 °C/-20 °C
- Storage Comment
- Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
- Expiry Date
- 24 months
-
- Target
- CD46
- Alternative Name
- CD46 / Membrane Cofactor Protein (CD46 Products)
- Synonyms
- AHUS2 antibody, MCP antibody, MIC10 antibody, TLX antibody, TRA2.10 antibody, Mcp antibody, CD46 antibody, CD46 molecule antibody, CD46 antigen, complement regulatory protein antibody, CD46 molecule, complement regulatory protein antibody, membrane cofactor protein-like antibody, CD46 antibody, Cd46 antibody, LOC100341359 antibody, LOC103789310 antibody
- Background
- Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
- Gene ID
- 4179
- UniProt
- P15529
- Pathways
- Regulation of Actin Filament Polymerization
-