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ERK1 antibody
MAPK3
Reactivity: Human, Mouse, Rat
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-ERK1 Antibody
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Target
See all ERK1 (MAPK3) Antibodies
ERK1 (MAPK3)
(Mitogen-Activated Protein Kinase 3 (MAPK3))
Reactivity
All reactivities for ERK1 antibodies
Human, Mouse, Rat
Host
All hosts for ERK1 antibodies
Rabbit
Clonality
All clonalities for ERK1 antibodies
Polyclonal
Conjugate
All conjugates for ERK1 antibodies
This ERK1 antibody is un-conjugated
Application
All applications for ERK1 antibodies
Western Blotting (WB)
Specificity
This antibody detects endogenous levels of ERK1/2 protein. (region surrounding His197)
Cross-Reactivity (Details)
Species reactivity (expected):Mouse and Rat. Species reactivity (tested):Human. Also reacts to: ERK2
Purification
Affinity chromatography using epitope-specific immunogen
Purity
> 95 % (by SDS-PAGE)
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Discover our top product MAPK3 Primary Antibody
Alternatives
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Application Details
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Application Notes
Western blot: 1: 500 - 1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Concentration
1.0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Target Details for ERK1
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Target
ERK1 (MAPK3)
(Mitogen-Activated Protein Kinase 3 (MAPK3))
Alternative Name
MAPK3 / ERK1 (MAPK3 Products )
Synonyms
ERK-1 antibody, ERK1 antibody, ERT2 antibody, HS44KDAP antibody, HUMKER1A antibody, P44ERK1 antibody, P44MAPK antibody, PRKM3 antibody, p44-ERK1 antibody, p44-MAPK antibody, Erk-1 antibody, Erk1 antibody, Ert2 antibody, Esrk1 antibody, Mnk1 antibody, Mtap2k antibody, Prkm3 antibody, p44 antibody, p44erk1 antibody, p44mapk antibody, ERK3 antibody, ERK6 antibody, P38GAMMA antibody, PRKM12 antibody, SAPK-3 antibody, SAPK3 antibody, fi06b09 antibody, wu:fi06b09 antibody, zERK1 antibody, Tb08.10J17.940 antibody, MAPK1 antibody, MNK1 antibody, AW123708 antibody, Erk6 antibody, P38gamma antibody, Prkm12 antibody, Sapk3 antibody, ATMAPK3 antibody, ATMPK3 antibody, T6D9.4 antibody, mitogen-activated protein kinase 3 antibody, mitogen-activated protein kinase 3 antibody, mitogen-activated protein kinase 12 antibody, mitogen activated protein kinase 3 antibody, mitogen-activated serine/threonine-protein kinase antibody, MAPK3 antibody, Mapk3 antibody, MAPK12 antibody, mapk3 antibody, Tc00.1047053509475.10 antibody, Tb927.8.3550 antibody, Mapk12 antibody, CEK1 antibody, MPK3 antibody
Background
The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular-signal related kinase 1 (ERK 1) and ERK 2, respectively. ERK proteins are regulated by dual phosphorylation at specific tyrosine and Threonine sites mapping within a characteristic Thr- Glu-Tyr motif. Phosphorylation at both the Thr and Tyr residues is required for full enzymatic activation. In response to activation, MAP kinases phos-phorylate downstream components on Serine and Threonine. Upstream MAP kinase regulators include MAP kinase kinase (MEK), MEK kinase and Raf-1. The ERK family has three additional members: ERK 3, ERK 5 and ERK 6.Synonyms: ERK-1, ERT2, Extracellular signal-regulated kinase 1, Insulin-stimulated MAP2 kinase, MAP kinase 3, MAP kinase isoform p44, MAPK 3, Microtubule-associated protein 2 kinase, Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 3, PRKM3, p44-ERK1, p44-MAPK
Molecular Weight
approx. 44,42 kDa
Gene ID
5595
NCBI Accession
NP_002737
UniProt
P27361
Pathways
MAPK Signaling , RTK Signaling , Interferon-gamma Pathway , Fc-epsilon Receptor Signaling Pathway , Neurotrophin Signaling Pathway , Response to Growth Hormone Stimulus , Activation of Innate immune Response , Cellular Response to Molecule of Bacterial Origin , Hepatitis C , Protein targeting to Nucleus , Toll-Like Receptors Cascades , Signaling Events mediated by VEGFR1 and VEGFR2 , Signaling of Hepatocyte Growth Factor Receptor , VEGFR1 Specific Signals , S100 Proteins
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