STAT2 antibody (pTyr690) (AbBy Fluor® 680)
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- Target See all STAT2 Antibodies
- STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))
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Binding Specificity
- pTyr690
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This STAT2 antibody is conjugated to AbBy Fluor® 680
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Specificity
- This phosphorylation site is homologous to that of Tyr689 in Mouse and Tyr690 in Rat.
- Cross-Reactivity
- Human, Mouse, Rat
- Predicted Reactivity
- Dog,Horse
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic phosphopeptide derived from human Stat2 around the phosphorylation site of Tyr690
- Isotype
- IgG
- Top Product
- Discover our top product STAT2 Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))
- Alternative Name
- Stat2 (STAT2 Products)
- Synonyms
- wu:fj84d07 antibody, p113 antibody, stat2 antibody, 1600010G07Rik antibody, AW496480 antibody, ISGF-3 antibody, P113 antibody, STAT113 antibody, signal transducer and activator of transcription 2 antibody, AGAP000099-PA antibody, stat2 antibody, STAT2 antibody, Stat2 antibody
- Background
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Synonyms: P113, ISGF-3, STAT113, Signal transducer and activator of transcription 2, STAT2
Background: Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
- Gene ID
- 6773
- UniProt
- P52630
- Pathways
- JAK-STAT Signaling, Hepatitis C, CXCR4-mediated Signaling Events
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