c-MET antibody (pTyr1349)

Catalog No. ABIN537685

Product Details anti-c-MET Antibody

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Binding Specificity: pTyr1349

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This c-MET antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit polyclonal antibody raised against synthetic phosphopeptide of MET.

Cross-Reactivity: Human

Immunogen: Synthetic phosphopeptide corresponding to amino acids 1345-1357 residues surrounding Y1349 of human MET.

Application Details

Application Notes: Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (0.09 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-c-MET antibody (ABIN537685)

Mineo, Costantino, Frasca, Sciacca, Russo, Vigneri, Belfiore: "Activation of the hepatocyte growth factor (HGF)-Met system in papillary thyroid cancer: biological effects of HGF in thyroid cancer cells depend on Met expression levels." in: Endocrinology, Vol. 145, Issue 9, pp. 4355-65, (2004) (PubMed).

Wong, Roskelley, Pelech, Miller, Leung, Auersperg: "Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation." in: Experimental cell research, Vol. 299, Issue 1, pp. 248-56, (2004) (PubMed).

Higuchi, Orita, Katsuya, Yamasaki, Akiyama, Li, Yamamoto, Saito, Nakamura: "MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met." in: Molecular and cellular biology, Vol. 24, Issue 17, pp. 7456-68, (2004) (PubMed).

Target Details for c-MET

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Alternative Name: HGF receptor (MET Products)

Synonyms: AUTS9 antibody, HGFR antibody, RCCP2 antibody, c-Met antibody, AI838057 antibody, HGF antibody, Par4 antibody, Hgfr antibody, c-met antibody, MET antibody, C-MET antibody, met antibody, met-A antibody, MET proto-oncogene, receptor tyrosine kinase antibody, met proto-oncogene antibody, MET proto-oncogene, receptor tyrosine kinase L homeolog antibody, MET antibody, Met antibody, met.L antibody

Gene ID: 4233

Pathways: RTK Signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor