AFT7 antibody (Middle Region)

Catalog No. ABIN5514514

Product Details anti-AFT7 Antibody

Target: AFT7 (Activating Transcription Factor 7 (AFT7))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AFT7 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GYDPLHPTLP SPTSVITQAP PSNRQMGSPT GSLPLVMHLA NGQTMPVLPG

Characteristics: This is a rabbit polyclonal antibody against ATF7. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human ATF7

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for AFT7

Target: AFT7 (Activating Transcription Factor 7 (AFT7))

Alternative Name: ATF7 (AFT7 Products)

Synonyms: ATFA antibody, 1110012F10Rik antibody, 9430065F09Rik antibody, AI549878 antibody, C130020M04Rik antibody, ATF7 antibody, fa97a09 antibody, fc25b12 antibody, wu:fa97a09 antibody, wu:fc25b12 antibody, atfa antibody, activating transcription factor 7 antibody, activating transcription factor 7b antibody, ATF7 antibody, Atf7 antibody, atf7b antibody, atf7 antibody

Background: Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation. FUNCTION: Isoform 4/ATF-A0 acts as a dominant repressor of the E- selectin/NF-ELAM1/delta-A promoter.ATF7 Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]- 3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.

Alias Symbols: ATF7, ATFA,

Protein Interaction Partner: FCER2, TMEM239, FAM9B, CCDC155, MITD1, OCIAD1, TAOK3, URI1, MAPK8, UBC, CREB1, Cebpb, SUMO2, YY1, BCL6, TAF12, TAF4, MAPK9, PTP4A1, PTP4A2, FOS, ATF2, JDP2,

Protein Size: 473

Gene ID: 11016