ATP6V0A4 antibody (Middle Region)

Catalog No. ABIN5514546

Product Details anti-ATP6V0A4 Antibody

Target: ATP6V0A4 (ATPase, H+ Transporting, Lysosomal V0 Subunit A4 (ATP6V0A4))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATP6V0A4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ADATRIKRAL EQGMELSGSS MAPIMTTVQS KTAPPTFNRT NKFTAGFQNI

Characteristics: This is a rabbit polyclonal antibody against ATP6V0A4. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human ATP6V0A4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ATP6V0A4

Target: ATP6V0A4 (ATPase, H+ Transporting, Lysosomal V0 Subunit A4 (ATP6V0A4))

Alternative Name: ATP6V0A4 (ATP6V0A4 Products)

Synonyms: A4 antibody, ATP6N1B antibody, ATP6N2 antibody, RDRTA2 antibody, RTA1C antibody, RTADR antibody, STV1 antibody, VPH1 antibody, VPP2 antibody, Atp6n1b antibody, a4 antibody, ATPase H+ transporting V0 subunit a4 antibody, ATPase, H+ transporting, lysosomal V0 subunit A4 antibody, ATP6V0A4 antibody, Atp6v0a4 antibody

Background: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing.

Alias Symbols: ATP6V0A4, ATP6N1B, ATP6N2,

Protein Interaction Partner: UBC, PFKM,

Protein Size: 940

Gene ID: 50617

UniProt: Q9HBG4

Pathways: Sensory Perception of Sound, Transition Metal Ion Homeostasis, Proton Transport