DIO2 antibody (Middle Region)

Catalog No. ABIN5514705

Product Details anti-DIO2 Antibody

Target: DIO2 (Deiodinase, Iodothyronine, Type II (DIO2))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DIO2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ILLKHVVLLL SRSKSTRGEW RRMLTSEGLR CVWKSFLLDA YKQVKLGEDA

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human DIO2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 23 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DIO2

Target: DIO2 (Deiodinase, Iodothyronine, Type II (DIO2))

Alternative Name: DIO2 (DIO2 Products)

Synonyms: 5DII antibody, D2 antibody, DIOII antibody, SelY antibody, TXDI2 antibody, AI324267 antibody, Deio2 antibody, cb684 antibody, DIO2 antibody, dio2-A antibody, 5dii antibody, sely antibody, txdi2 antibody, iodothyronine deiodinase 2 antibody, deiodinase, iodothyronine, type II antibody, deiodinase, iodothyronine, type 2 L homeolog antibody, deiodinase, iodothyronine, type 2 antibody, type II iodothyronine deiodinase antibody, DIO2 antibody, Dio2 antibody, dio2 antibody, dio2.L antibody, LOC100861220 antibody

Background: The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alias Symbols: D2, 5DII, SelY, DIOII, TXDI2,

Protein Size: 273

Gene ID: 1734

NCBI Accession: NM_000793, NP_000784

UniProt: Q92813

Pathways: Hormone Transport, Hormone Activity