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DIO2 antibody (Middle Region)

DIO2 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5514705
  • Target See all DIO2 Antibodies
    DIO2 (Deiodinase, Iodothyronine, Type II (DIO2))
    Binding Specificity
    • 15
    • 9
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 28
    • 25
    • 21
    Human
    Host
    • 43
    • 1
    • 1
    Rabbit
    Clonality
    • 44
    • 1
    Polyclonal
    Conjugate
    • 16
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DIO2 antibody is un-conjugated
    Application
    • 32
    • 18
    • 13
    • 13
    • 8
    • 7
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    ILLKHVVLLL SRSKSTRGEW RRMLTSEGLR CVWKSFLLDA YKQVKLGEDA
    Purification
    Affinity purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human DIO2
    Top Product
    Discover our top product DIO2 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 23 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    DIO2 (Deiodinase, Iodothyronine, Type II (DIO2))
    Alternative Name
    DIO2 (DIO2 Products)
    Synonyms
    5DII antibody, D2 antibody, DIOII antibody, SelY antibody, TXDI2 antibody, AI324267 antibody, Deio2 antibody, cb684 antibody, DIO2 antibody, dio2-A antibody, 5dii antibody, sely antibody, txdi2 antibody, iodothyronine deiodinase 2 antibody, deiodinase, iodothyronine, type II antibody, deiodinase, iodothyronine, type 2 L homeolog antibody, deiodinase, iodothyronine, type 2 antibody, type II iodothyronine deiodinase antibody, DIO2 antibody, Dio2 antibody, dio2 antibody, dio2.L antibody, LOC100861220 antibody
    Background
    The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.

    Alias Symbols: D2, 5DII, SelY, DIOII, TXDI2,

    Protein Size: 273
    Gene ID
    1734
    NCBI Accession
    NM_000793, NP_000784
    UniProt
    Q92813
    Pathways
    Hormone Transport, Hormone Activity
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