SP100 antibody (Middle Region)

Catalog No. ABIN5515158

Product Details anti-SP100 Antibody

Target: SP100 (SP100 Nuclear Antigen (SP100))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SP100 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: IIVISSEDSE GSTDVDEPLE VFISAPRSEP VINNDNPLES NDEKEGQEAT

Characteristics: This is a rabbit polyclonal antibody against SP100. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human SP100

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SP100

Target: SP100 (SP100 Nuclear Antigen (SP100))

Alternative Name: SP100 (SP100 Products)

Synonyms: SP100 antibody, A430075G10Rik antibody, lysp100b antibody, SP140 antibody, SP100 nuclear antigen antibody, nuclear antigen Sp100 antibody, nuclear autoantigen Sp-100 antibody, SP100 antibody, Sp100 antibody, LOC101120993 antibody

Background: This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene, one of which encodes a high-mobility group protein.

Alias Symbols: SP100,

Protein Interaction Partner: RBM39, DYRK2, SUMO1, UBE2I, SP100, SUMO2, SUMO3, PHC1, DNMT3A, ACTN2, RTP5, L3MBTL3, TRAF3IP3, GIPC2, AMOTL2, ZC2HC1A, SENP1, CBX5, USPL1, UBC, PML, VPS25, PUS1, CRTAP, TOM1L1, SERPINE2, AGL, CREM, DSTN, AHCYL1, SEC23A, IGBP1, ETS1, ARID3A, TERF2IP, TERF2

Protein Size: 879

Gene ID: 6672

NCBI Accession: NP_003104

UniProt: P23497

Pathways: Retinoic Acid Receptor Signaling Pathway