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SP100 antibody (Middle Region)
SP100
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-SP100 Antibody
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Target
See all SP100 Antibodies
SP100
(SP100 Nuclear Antigen (SP100))
Binding Specificity
All epitopes for SP100 antibodies
Middle Region
Reactivity
All reactivities for SP100 antibodies
Human
Host
All hosts for SP100 antibodies
Rabbit
Clonality
All clonalities for SP100 antibodies
Polyclonal
Conjugate
All conjugates for SP100 antibodies
This SP100 antibody is un-conjugated
Application
All applications for SP100 antibodies
Western Blotting (WB)
Sequence
IIVISSEDSE GSTDVDEPLE VFISAPRSEP VINNDNPLES NDEKEGQEAT
Characteristics
This is a rabbit polyclonal antibody against SP100. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Human SP100
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for SP100
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Target
SP100
(SP100 Nuclear Antigen (SP100))
Alternative Name
SP100 (SP100 Products )
Synonyms
SP100 antibody, A430075G10Rik antibody, lysp100b antibody, SP140 antibody, SP100 nuclear antigen antibody, nuclear antigen Sp100 antibody, nuclear autoantigen Sp-100 antibody, SP100 antibody, Sp100 antibody, LOC101120993 antibody
Background
This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene, one of which encodes a high-mobility group protein. Alias Symbols: SP100, Protein Interaction Partner: RBM39, DYRK2, SUMO1, UBE2I, SP100, SUMO2, SUMO3, PHC1, DNMT3A, ACTN2, RTP5, L3MBTL3, TRAF3IP3, GIPC2, AMOTL2, ZC2HC1A, SENP1, CBX5, USPL1, UBC, PML, VPS25, PUS1, CRTAP, TOM1L1, SERPINE2, AGL, CREM, DSTN, AHCYL1, SEC23A, IGBP1, ETS1, ARID3A, TERF2IP, TERF2 Protein Size: 879
Gene ID
6672
NCBI Accession
NP_003104
UniProt
P23497
Pathways
Retinoic Acid Receptor Signaling Pathway
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