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SHC1 antibody (Middle Region)
SHC1
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-SHC1 Antibody
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Target
See all SHC1 Antibodies
SHC1
(SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
Binding Specificity
All epitopes for SHC1 antibodies
Middle Region
Reactivity
All reactivities for SHC1 antibodies
Human
Host
All hosts for SHC1 antibodies
Rabbit
Clonality
All clonalities for SHC1 antibodies
Polyclonal
Conjugate
All conjugates for SHC1 antibodies
This SHC1 antibody is un-conjugated
Application
All applications for SHC1 antibodies
Western Blotting (WB)
Sequence
EPPDHQYYND FPGKEPPLGG VVDMRLREGA APGAARPTAP NAQTPSHLGA
Purification
Affinity purified
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human SHC1
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for SHC1
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Target
SHC1
(SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
Alternative Name
SHC1 (SHC1 Products )
Synonyms
SHC1 antibody, SHC antibody, SHCA antibody, P66shc antibody, si:dkey-246i14.4 antibody, wu:fc10h03 antibody, shc antibody, p66shc antibody, Shc antibody, ShcA antibody, p66 antibody, SHC adaptor protein 1 antibody, Shc1p antibody, squalene--hopene cyclase antibody, SHC (Src homology 2 domain containing) transforming protein 1 antibody, SHC (Src homology 2 domain containing) transforming protein 1 L homeolog antibody, src homology 2 domain-containing transforming protein C1 antibody, SHC1 antibody, shc1 antibody, Shc1 antibody, shc1.L antibody
Background
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. Alias Symbols: SHC, SHCA Protein Size: 167
Gene ID
6464
NCBI Accession
NM_001130040 , NP_001123512
UniProt
P29353
Pathways
RTK Signaling , TCR Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , ER-Nucleus Signaling , Signaling Events mediated by VEGFR1 and VEGFR2
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