RUNX3 antibody (C-Term)

Catalog No. ABIN5516157

Product Details anti-RUNX3 Antibody

Target: RUNX3 (Runt-Related Transcription Factor 3 (RUNX3))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RUNX3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PQNQSGPFQA NPSPYHLYYG TSSGSYQFSM VAGSSSGGDR SPTRMLASCT

Characteristics: This is a rabbit polyclonal antibody against RUNX3. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human RUNX3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RUNX3

Target: RUNX3 (Runt-Related Transcription Factor 3 (RUNX3))

Alternative Name: RUNX3 (RUNX3 Products)

Synonyms: runxb antibody, RUNX3 antibody, CBFA3 antibody, frrunx3 antibody, runx3 antibody, aml2 antibody, cbfa3 antibody, pebp2ac antibody, AML2 antibody, Cbfa3 antibody, Pebp2a3 antibody, PEBP2aC antibody, runt-related transcription factor 3 antibody, runt related transcription factor 3 antibody, runt related transcription factor 3 L homeolog antibody, runx3 antibody, RUNX3 antibody, runx3.L antibody, Runx3 antibody

Background: This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Alias Symbols: RUNX3, AML2, CBFA3, PEBP2A3,

Protein Interaction Partner: Dlg4, UBC, PML, PIN1, NOTCH1, RBPJ, SIRT2, Cdk4, MDM2, EZH2, Vdr, SMURF2, SMURF1, HDAC9, SUV39H1, SMAD3, EP300, CBFB, SP110, HDAC5, HDAC4, HDAC2, HDAC1, TLE1, SMAD1, YAP1, SMAD5, SMAD2, PHB2,

Protein Size: 415

Gene ID: 864

UniProt: Q13761