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FLT3 antibody (N-Term)
FLT3
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-FLT3 Antibody
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Target
See all FLT3 Antibodies
FLT3
(Fms-Related tyrosine Kinase 3 (FLT3))
Binding Specificity
All epitopes for FLT3 antibodies
N-Term
Reactivity
All reactivities for FLT3 antibodies
Human
Host
All hosts for FLT3 antibodies
Rabbit
Clonality
All clonalities for FLT3 antibodies
Polyclonal
Conjugate
All conjugates for FLT3 antibodies
This FLT3 antibody is un-conjugated
Application
All applications for FLT3 antibodies
Western Blotting (WB)
Sequence
FGTITNQDLP VIKCVLINHK NNDSSVGKSS SYPMVSESPE DLGCALRPQS
Purification
Affinity purified
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human FLT3
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for FLT3
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Target
FLT3
(Fms-Related tyrosine Kinase 3 (FLT3))
Alternative Name
FLT3 (FLT3 Products )
Synonyms
FLT3 antibody, B230315G04 antibody, CD135 antibody, Flk-2 antibody, Flk2 antibody, Flt-3 antibody, Ly72 antibody, wmfl antibody, FLK-2 antibody, FLK2 antibody, STK1 antibody, fms related tyrosine kinase 3 antibody, FMS-like tyrosine kinase 3 antibody, fms-related tyrosine kinase 3 antibody, FLT3 antibody, Flt3 antibody
Background
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. Alias Symbols: FLK2, STK1, CD135, FLK-2 Protein Size: 952
Gene ID
2322
NCBI Accession
NM_004119 , NP_004110
Pathways
RTK Signaling
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