This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This PTPRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-316 amino acids from the Central region of human PTPRN.
PTPRN
Reactivity: Human, Rat, Mouse
WB
Host: Rabbit
Polyclonal
unconjugated
Application Notes
For WB starting dilution is: 1:1000
Restrictions
For Research Use only
Format
Liquid
Concentration
0.5 mg/mL
Buffer
Supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Target
PTPRN
(Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN))
IA-2 antibody, IA-2/PTP antibody, IA2 antibody, ICA512 antibody, R-PTP-N antibody, mIA-A antibody, mKIAA4064 antibody, Ia-2 antibody, fc43c04 antibody, ptprn antibody, wu:fc43c04 antibody, ia-2 antibody, ia2 antibody, ica512 antibody, r-ptp-n antibody, protein tyrosine phosphatase, receptor type N antibody, protein tyrosine phosphatase, receptor type, N antibody, protein tyrosine phosphatase, receptor type, Na antibody, protein tyrosine phosphatase, receptor type N L homeolog antibody, PTPRN antibody, Ptprn antibody, ptprna antibody, ptprn.L antibody
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.