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ORAI3 antibody (C-Term)

ORAI3 Reactivity: Human, Mouse WB, IF, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500427
  • Target See all ORAI3 Antibodies
    ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))
    Binding Specificity
    • 13
    • 10
    • 8
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 25
    • 8
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 22
    • 3
    Rabbit
    Clonality
    • 22
    • 3
    Polyclonal
    Conjugate
    • 15
    • 2
    • 2
    • 2
    • 2
    • 2
    This ORAI3 antibody is un-conjugated
    Application
    • 25
    • 17
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects ORAI3 at C-term. It i predicted to have no cross-reactivity to ORAI1 or ORAI2.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, mouse
    Purification
    Peptide affinity chromatography
    Immunogen
    ORAI3 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human ORAI3.
    Isotype
    IgG
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  • Application Notes
    ELISA. Western blot: 2 - 4 μg/mL. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))
    Alternative Name
    ORAI3 (ORAI3 Products)
    Synonyms
    ORAI3 antibody, TMEM142C antibody, 9930124N15 antibody, BC061259 antibody, Tmem142c antibody, RGD1306538 antibody, ORAI calcium release-activated calcium modulator 3 antibody, ORAI3 antibody, Orai3 antibody
    Background
    Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter.Synonyms: ORAI-3, TMEM142C, Transmembrane Protein 142C
    Gene ID
    93129
    UniProt
    Q9BRQ5
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