JAG1 antibody

Catalog No. ABIN5688811

Product Details anti-JAG1 Antibody

Target: JAG1 (Jagged 1 (JAG1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This JAG1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Specificity: Recognizes human Jagged-1. Detects a band of ~180  kDa by Western blot.

Immunogen: Recombinant human Jagged-1.

Clone: J1G53-3

Isotype: IgG1 kappa

Application Details

Application Notes: ELISA: (direct or indirect: 1:500-1:5,000). Flow Cytometry: (1:20-1:100). Immunohistochemistry: (paraffin sections). Western blot: (1:500-1:5,000 using ECL. Suggested blocking and dilution buffer is PBST with 0.05 % Tween 20 and 5 % skim milk. Suggested incubation time is 1 hour at rooom temperature). Optimal conditions should be determined individually for each application.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. 0.2um-filtered solution in PBS,  pH 7.4. Contains no preservatives.

Preservative: Without preservative

Storage: -20 °C

Storage Comment: Stable for at least 1 year after receipt when stored at -20°C.

Target Details for JAG1

Target: JAG1 (Jagged 1 (JAG1))

Alternative Name: Jagged-1 (JAG1 Products)

Synonyms: AGS antibody, AHD antibody, AWS antibody, CD339 antibody, HJ1 antibody, JAGL1 antibody, ABE2 antibody, Gsfabe2 antibody, Htu antibody, Ozz antibody, Ser-1 antibody, JAG1 antibody, jag3 antibody, cb243 antibody, jag1 antibody, sb:cb243 antibody, serrateC antibody, jagged1 antibody, serrate antibody, serrate-1 antibody, x-serrate-1 antibody, jagged 1 antibody, jagged 1b antibody, jagged 1a antibody, jagged 1 L homeolog antibody, JAG1 antibody, Jag1 antibody, jag1 antibody, jag1b antibody, jag1a antibody, jag1.L antibody

Background: Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF).

Gene ID: 182

NCBI Accession: NP_000205

UniProt: P78504

Pathways: Notch Signaling, Stem Cell Maintenance