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SHC1 antibody (AA 347-351)
SHC1
Reactivity: Human, Mouse
WB, IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-SHC1 Antibody
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Target
See all SHC1 Antibodies
SHC1
(SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
Binding Specificity
All epitopes for SHC1 antibodies
AA 347-351
Reactivity
All reactivities for SHC1 antibodies
Human, Mouse
Host
All hosts for SHC1 antibodies
Rabbit
Clonality
All clonalities for SHC1 antibodies
Polyclonal
Conjugate
All conjugates for SHC1 antibodies
This SHC1 antibody is un-conjugated
Application
All applications for SHC1 antibodies
Western Blotting (WB), Immunofluorescence (IF)
Specificity
This antibody detects endogenous level of total Shc1 protein.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
Shc1 (Ab-349) antibody was raised against a peptide sequence around aa.347~351 (H-Q-Y-Y-N) derived from Human Shc1.
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Alternatives
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Application Details
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Application Notes
Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store antibody at -20°C for up to one year.
Target Details for SHC1
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Target
SHC1
(SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
Alternative Name
Shc1 (SHC1 Products )
Synonyms
SHC1 antibody, SHC antibody, SHCA antibody, P66shc antibody, si:dkey-246i14.4 antibody, wu:fc10h03 antibody, shc antibody, p66shc antibody, Shc antibody, ShcA antibody, p66 antibody, SHC adaptor protein 1 antibody, Shc1p antibody, squalene--hopene cyclase antibody, SHC (Src homology 2 domain containing) transforming protein 1 antibody, SHC (Src homology 2 domain containing) transforming protein 1 L homeolog antibody, src homology 2 domain-containing transforming protein C1 antibody, SHC1 antibody, shc1 antibody, Shc1 antibody, shc1.L antibody
Background
Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span
Molecular Weight
46, 52, 66 kDa
Gene ID
6464
NCBI Accession
NP_001123512
UniProt
P29353
Pathways
RTK Signaling , TCR Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , ER-Nucleus Signaling , Signaling Events mediated by VEGFR1 and VEGFR2
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