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Osteopontin antibody (AA 50-100)
SPP1
Reactivity: Human, Mouse, Rat
WB, ELISA, IHC (p), IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-Osteopontin Antibody
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Target
See all Osteopontin (SPP1) Antibodies
Osteopontin (SPP1)
(Secreted phosphoprotein 1 (SPP1))
Binding Specificity
All epitopes for Osteopontin antibodies
AA 50-100
Reactivity
All reactivities for Osteopontin antibodies
Human, Mouse, Rat
Host
All hosts for Osteopontin antibodies
Rabbit
Clonality
All clonalities for Osteopontin antibodies
Polyclonal
Conjugate
All conjugates for Osteopontin antibodies
This Osteopontin antibody is un-conjugated
Application
All applications for Osteopontin antibodies
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
Specificity
SPP1 antibody is human, mouse and rat reactive. Multiple isoforms of SPP1 are known to exist.
Purification
SPP1 Antibody is affinity chromatography purified via peptide column.
Immunogen
SPP1 antibody was raised against an 18 amino acid peptide near the amino terminus of human SPP1. The immunogen is located within amino acids 50 - 100 of SPP1.
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
SPP1 antibody can be used for detection of SPP1 by Western blot at 1 - 2 μ,g/mL.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
SPP1 Antibody is supplied in PBS containing 0.02 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
SPP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Target Details for Osteopontin
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Target
Osteopontin (SPP1)
(Secreted phosphoprotein 1 (SPP1))
Alternative Name
SPP1 (SPP1 Products )
Synonyms
BNSP antibody, BSPI antibody, ETA-1 antibody, OPN antibody, 2AR antibody, Apl-1 antibody, Bsp antibody, Eta antibody, OP antibody, Opn antibody, Opnl antibody, Ric antibody, Spp-1 antibody, OSP antibody, zgc:111821 antibody, secreted phosphoprotein 1 antibody, SPP1 antibody, Spp1 antibody, spp1 antibody
Background
SPP1 Antibody: The secreted protein 1 (SPP1), also known as osteopontin, is a major noncollagenous protein of bone, but is also found in the extracellular matrix of other mineralized tissues and in bodily fluids. In bone, SPP1 is produced by osteoblasts, osteocytes, macrophages, and osteoclasts (1,2). SPP1 binds to cells through integrin and non-integrin receptors, as well as the adhesion receptor CD44 in an RGD-independent manner, enabling SPP1 to induce a number of functional effects including macrophage chemotaxis, cytoprotection, and regulation of T helper type 1 cells (2). SPP1 can regulate biomineralization by inhibiting the formation of hydroxyapatite (3) and the growth of calcium oxalate crystals (4).
Molecular Weight
Predicted: 36 kDa Observed: 37 kDa
Gene ID
6696
NCBI Accession
NP_001238759
UniProt
P10451
Pathways
Regulation of Cell Size
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