SIRT5 antibody

Catalog No. ABIN5699361

Product Details anti-SIRT5 Antibody

Target: SIRT5 (Sirtuin 5 (SIRT5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIRT5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Immunogen: sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for SIRT5

Target: SIRT5 (Sirtuin 5 (SIRT5))

Alternative Name: SIRT5 (SIRT5 Products)

Synonyms: SIR2L5 antibody, 0610012J09Rik antibody, 1500032M05Rik antibody, AV001953 antibody, zgc:92288 antibody, sirt5-a antibody, SIRT5 antibody, sir2l5 antibody, sirtuin 5 antibody, sirtuin 5 L homeolog antibody, SIRT5 antibody, Sirt5 antibody, sirt5 antibody, sirt5.L antibody, CC1G_00083 antibody

Background: Synonyms:FLJ36950, SIR2 like protein 5, SIR2L5, SIRT5 Background:NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins(PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting(PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species(PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2(By similarity). Has weak NAD-dependent protein deacetylase activity, however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c(CYCS) and a number of other proteins in vitro such as UOX.

Gene ID: 23408

UniProt: Q9NXA8

Pathways: SARS-CoV-2 Protein Interactome