DDX21 antibody
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- Target See all DDX21 Antibodies
- DDX21 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 21 (DDX21))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This DDX21 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA, Immunoprecipitation (IP)
- Immunogen
- DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
- Isotype
- IgG
- Top Product
- Discover our top product DDX21 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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HepG2 cells were subjected to SDS PAGE followed by western blot with FNab02299(DDX21 antibody) at dilution of 1:2000
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- DDX21 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 21 (DDX21))
- Alternative Name
- DDX21 (DDX21 Products)
- Synonyms
- MGC130693 antibody, DDX21 antibody, cb960 antibody, wu:fi30c07 antibody, wu:fi34d08 antibody, GUA antibody, GURDB antibody, RH-II/GU antibody, RH-II/GuA antibody, Ddx21a antibody, AI255159 antibody, AL022742 antibody, D10Ertd645e antibody, D10Wsu42e antibody, DEAD-box helicase 21 L homeolog antibody, DExD-box helicase 21 antibody, DEAD-box helicase 21 antibody, DEAD (Asp-Glu-Ala-Asp) box helicase 21 antibody, DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 antibody, ddx21.L antibody, DDX21 antibody, ddx21 antibody, Ddx21 antibody
- Background
- Synonyms: Background:RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase(Pol) I and II: promotes ribosomal RNA(rRNA) processing and transcription from polymerase II(Pol II)(PubMed:25470060). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs(PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes(PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes(PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77'(PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA(helicase) and can fold or introduce a secondary structure to a single-stranded RNA(foldase)(PubMed:9461305). Involved in rRNA processing(PubMed:14559904, PubMed:18180292).
- Molecular Weight
- 87 kDa
- Gene ID
- 9188
- UniProt
- Q9NR30
- Pathways
- SARS-CoV-2 Protein Interactome
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