IFITM3 antibody
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- Target See all IFITM3 Antibodies
- IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This IFITM3 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
- Immunogen
- interferon induced transmembrane protein 3 (1-8U)
- Isotype
- IgG
- Top Product
- Discover our top product IFITM3 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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mouse colon tissue were subjected to SDS PAGE followed by western blot with FNab04144( IFITM3 Antibody) at dilution of 1:1000
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))
- Alternative Name
- IFITM3 (IFITM3 Products)
- Synonyms
- 1110004C05Rik antibody, Cd225 antibody, Cdw217 antibody, DSPA2b antibody, Fgls antibody, IP15 antibody, mil-1 antibody, 1-8U antibody, rat8 antibody, Interferon-induced transmembrane protein 3 antibody, interferon induced transmembrane protein 3 antibody, ifm3 antibody, Ifitm3 antibody, IFITM3 antibody
- Background
- Synonyms:1 8U, IFITM3, IP15 Background:IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus(SARS-CoV), Marburg virus(MARV) and Ebola virus(EBOV), Dengue virus(DNV), West Nile virus(WNV), human immunodeficiency virus type 1(HIV-1) and vesicular stomatitis virus(VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase(v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.
- Molecular Weight
- 14 kDa
- Gene ID
- 10410
- UniProt
- Q01628
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