RECQL2 antibody

Catalog No. ABIN5701434

Product Details anti-RECQL2 Antibody

Target: RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RECQL2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Immunogen: Werner syndrome, RecQ helicase-like

Isotype: IgG

Application Details

Application Notes: WB:1:200-1:1000

Comment:

MCF-7 cells were subjected to SDS PAGE followed by western blot with FNab09524( WRN Antibody) at dilution of 1:300

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for RECQL2

Target: RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))

Alternative Name: WRN (WRN Products)

Synonyms: RECQ3 antibody, RECQL2 antibody, RECQL3 antibody, xBLM antibody, recq2 antibody, recql2 antibody, recql3 antibody, AI846146 antibody, ffa-1 antibody, xwrn antibody, RGD1564788 antibody, Werner syndrome RecQ like helicase antibody, mediator of RNA polymerase II transcription subunit 34 antibody, Bloom syndrome RecQ like helicase antibody, Werner syndrome, RecQ helicase-like L homeolog antibody, WRN antibody, LOC9327212 antibody, blm antibody, Wrn antibody, wrn.L antibody

Background: Synonyms:DKFZp686C2056, DNA helicase, RecQ like type 3, Exonuclease WRN, RecQ protein like 2, RECQ3, RECQL2, RECQL3, WRN Background:Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers, stably associates with foci elements generating binding sites for RP-A(By similarity). Plays a role in double-strand break repair after gamma-irradiation.

Molecular Weight: 59kDa,Observed 72kDa

Gene ID: 7486

UniProt: Q14191

Pathways: DNA Damage Repair