PIEZO1 antibody

Catalog No. ABIN5705358

Product Details anti-PIEZO1 Antibody

Target: PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIEZO1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Immunogen: family with sequence similarity 38, member A

Isotype: IgG

Application Details

Application Notes: WB : 1:200-1:1000 IHC : 1:50-1:500

Comment:

HepG2 cells were subjected to SDS PAGE followed by western blot with FNab06435(Piezo1 antibody) at dilution of 1:500

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Expiry Date: 12 months

Target Details for PIEZO1

Target: PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))

Alternative Name: Piezo1 (PIEZO1 Products)

Synonyms: DHS antibody, FAM38A antibody, Mib antibody, 9630020g22 antibody, Fam38a antibody, mKIAA0233 antibody, piezo type mechanosensitive ion channel component 1 antibody, piezo-type mechanosensitive ion channel component 1 antibody, PIEZO1 antibody, Piezo1 antibody

Background: Synonyms:FAM38A, KIAA0233 Background:Pore-forming subunit of a mechanosensitive non-specific cation channel(PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling(PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation(PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology(By similarity).

Molecular Weight: 250 kDa

Gene ID: 9780

UniProt: Q92508