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IRS1 antibody
IRS1
Reactivity: Human
WB, IHC, IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-IRS1 Antibody
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Target
See all IRS1 Antibodies
IRS1
(Insulin Receptor Substrate 1 (IRS1))
Reactivity
All reactivities for IRS1 antibodies
Human
Host
All hosts for IRS1 antibodies
Rabbit
Clonality
All clonalities for IRS1 antibodies
Polyclonal
Conjugate
All conjugates for IRS1 antibodies
This IRS1 antibody is un-conjugated
Application
All applications for IRS1 antibodies
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Cross-Reactivity
Human, Mouse, Rat
Characteristics
Polyclonal Antibodies
Immunogen
Recombinant protein of human IRS1
Isotype
IgG
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Discover our top product IRS1 Primary Antibody
Alternatives
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Application Details
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Application Notes
WB,1:500 - 1:1000,IHC,1:50 - 1:100,IF,1:50 - 1:100
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid freeze / thaw cycles
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
References for anti-IRS1 antibody (ABIN6213716)
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Yan, Wang, Jin, Meng, Liu, Liu, Liu, Sun : "Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway. " in: Pharmacological research , Vol. 130 , pp. 466-480 , (2019 ) (PubMed ).
Zhang, Zhang, Tang, Gao, Sun, Yang, Zhou, Hu, Ke, Wu, Ding, Guo, Pei, Chen, Sy, Zhang, Li : "CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling. " in: Hepatology (Baltimore, Md.) , Vol. 68 , Issue 5 , pp. 1710-1725 , (2018 ) (PubMed ).
Target Details for IRS1
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Target
IRS1
(Insulin Receptor Substrate 1 (IRS1))
Alternative Name
IRS1 (IRS1 Products )
Synonyms
HIRS-1 antibody, G972R antibody, IRS-1 antibody, IRS1IRM antibody, irs1 antibody, irsu antibody, IRS1 antibody, irs-1 antibody, irs1-a antibody, insulin receptor substrate 1 antibody, insulin receptor substrate 2 antibody, insulin receptor substrate 1 S homeolog antibody, IRS1 antibody, Irs1 antibody, irs2 antibody, irs1.S antibody
Background
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.,HIRS-1,IRS1,Epigenetics & Nuclear Signaling,Translation Control,Regulation of eIF4 and p70 S6 Kinase,Cancer,Signal Transduction,PI3K-Akt Signaling Pathway,mTOR Signaling Pathway,MAPK-Erk Signaling Pathway,MAPK-JNK Signaling Pathway,Cell Biology & Developmental Biology,Growth factor,Endocrine & Metabolism,Insulin Receptor Signaling Pathway,Endocrine and metabolic diseases,Diabetes,Obesity,Immunology & Inflammation,Neuroscience,Cell Type Marker,Cardiovascular,Heart,Cardiovascular diseases,Heart disease,IRS1
Molecular Weight
131 kDa
Gene ID
3667
UniProt
P35568
Pathways
Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Positive Regulation of Peptide Hormone Secretion , Hormone Transport , Negative Regulation of Hormone Secretion , Response to Growth Hormone Stimulus , Carbohydrate Homeostasis , Regulation of Carbohydrate Metabolic Process
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