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PPP3CA antibody (AA 1-511)
PPP3CA
Reactivity: Human
WB, IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-PPP3CA Antibody
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Target
See all PPP3CA Antibodies
PPP3CA
(Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))
Binding Specificity
All epitopes for PPP3CA antibodies
AA 1-511
Reactivity
All reactivities for PPP3CA antibodies
Human
Host
All hosts for PPP3CA antibodies
Rabbit
Clonality
All clonalities for PPP3CA antibodies
Polyclonal
Conjugate
All conjugates for PPP3CA antibodies
This PPP3CA antibody is un-conjugated
Application
All applications for PPP3CA antibodies
Western Blotting (WB), Immunofluorescence (IF)
Sequence
MSEPKAIDPK LSTTDRVVKA VPFPPSHRLT AKEVFDNDGK PRVDILKAHL MKEGRLEESV ALRIITEGAS ILRQEKNLLD IDAPVTVCGD IHGQFFDLMK LFEVGGSPAN TRYLFLGDYV DRGYFSIECV LYLWALKILY PKTLFLLRGN HECRHLTEYF TFKQECKIKY SERVYDACMD AFDCLPLAAL MNQQFLCVHG GLSPEINTLD DIRKLDRFKE PPAYGPMCDI LWSDPLEDFG NEKTQEHFTH NTVRGCSYFY SYPAVCEFLQ HNNLLSILRA HEAQDAGYRM YRKSQTTGFP SLITIFSAPN YLDVYNNKAA VLKYENNVMN IRQFNCSPHP YWLPNFMDVF TWSLPFVGEK VTEMLVNVLN ICSDDELGSE EDGFDGATAA ARKEVIRNKI RAIGKMARVF SVLREESESV LTLKGLTPTG MLPSGVLSGG KQTLQSAIKG FSPQHKITSF EEAKGLDRIN ERMPPRRDAM PSDANLNSIN KALTSETNGT DSNGSNSSNI Q
Cross-Reactivity
Human, Mouse
Characteristics
Polyclonal Antibodies
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-511 of human Calcineurin A (NP_001124163.1).
Isotype
IgG
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Discover our top product PPP3CA Primary Antibody
Alternatives
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anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) (Middle Region) antibody
PPP3CA
Reactivity: Human, Mouse, Rat, Dog, Cow, Rabbit, Horse, Zebrafish (Danio rerio), Guinea Pig
WB
Host: Rabbit
Polyclonal
unconjugated
anti-Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA) (N-Term) antibody
PPP3CA
Reactivity: Human, Mouse, Rat, Dog, Cow, Rabbit, Horse, Pig, Zebrafish (Danio rerio)
WB
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Application Notes
WB,1:500 - 1:2000,IF,1:50 - 1:200
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid freeze / thaw cycles
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
References for anti-PPP3CA antibody (ABIN6214918)
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Chen, Wang, Long, Jia, Zhang, Deng, Li, Han, Wang : "Fasting-induced hormonal regulation of lysosomal function. " in: Cell research , Vol. 27 , Issue 6 , pp. 748-763 , (2018 ) (PubMed ).
Target Details for PPP3CA
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Target
PPP3CA
(Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))
Alternative Name
PPP3CA (PPP3CA Products )
Synonyms
CALN antibody, CALNA antibody, CALNA1 antibody, CCN1 antibody, CNA1 antibody, PPP2B antibody, 2900074D19Rik antibody, AI841391 antibody, AW413465 antibody, CN antibody, Caln antibody, Calna antibody, CnA antibody, Calna1 antibody, calcineurin antibody, caln antibody, calna antibody, calna1 antibody, ccn1 antibody, cna1 antibody, ppp2b antibody, fj46e08 antibody, si:dkeyp-79c2.2 antibody, wu:fj46e08 antibody, ppp3ca antibody, protein phosphatase 3 catalytic subunit alpha antibody, protein phosphatase 3, catalytic subunit, alpha isoform antibody, protein phosphatase 3, catalytic subunit, alpha isozyme antibody, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha) antibody, protein phosphatase 3, catalytic subunit, alpha isozyme L homeolog antibody, serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform antibody, PPP3CA antibody, Ppp3ca antibody, ppp3ca antibody, ppp3ca.L antibody, LOC100205420 antibody
Background
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+ levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation. In response to increased Ca(2+ levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion. Dephosphorylates heat shock protein HSPB1 (By similarity. Dephosphorylates and activates transcription factor NFATC1. In response to increased Ca(2+ levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins. Dephosphorylates transcription factor TFEB at 'Ser-211' following Coxsackievirus B3 infection, promoting nuclear translocation.,PPP3CA,CALN,CALNA,CALNA1,CCN1,CNA1,PPP2B,Signal Transduction,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Cytoskeleton,Actins,Immunology & Inflammation,B Cell Receptor Signaling Pathway,T Cell Receptor Signaling Pathway,Neuroscience,Calcium Signaling,Neurodegenerative Diseases,PPP3CA
Molecular Weight
31 kDa/51 kDa/52 kDa/57 kDa/58 kDa
Gene ID
5530
UniProt
Q08209
Pathways
RTK Signaling , WNT Signaling , Fc-epsilon Receptor Signaling Pathway , Negative Regulation of Hormone Secretion , Carbohydrate Homeostasis , Synaptic Membrane , Skeletal Muscle Fiber Development , Protein targeting to Nucleus , VEGF Signaling , BCR Signaling
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