SP100 antibody (Internal Region)
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- Target See all SP100 Antibodies
- SP100 (SP100 Nuclear Antigen (SP100))
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Binding Specificity
- Internal Region
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SP100 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
- Specificity
- SP100 Antibody detects endogenous levels of total SP100.
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human SP100, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product SP100 Primary Antibody
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- Application Notes
- WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- SP100 (SP100 Nuclear Antigen (SP100))
- Alternative Name
- SP100 (SP100 Products)
- Synonyms
- SP100 antibody, A430075G10Rik antibody, lysp100b antibody, SP140 antibody, SP100 nuclear antigen antibody, nuclear antigen Sp100 antibody, nuclear autoantigen Sp-100 antibody, SP100 antibody, Sp100 antibody, LOC101120993 antibody
- Background
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Description: Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.
Gene: SP100
- Molecular Weight
- 0 kDa
- Gene ID
- 6672
- UniProt
- P23497
- Pathways
- Retinoic Acid Receptor Signaling Pathway
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