ROR2 antibody

Catalog No. ABIN6938323

Product Details anti-ROR2 Antibody

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ROR2 antibody is un-conjugated

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificity: ROR2 (receptor tyrosine kinase-like orphan receptor 2), also known as neurotrophic tyrosine kinase receptor-related 2 (NTRKR2), is a single pass transmembrane tyrosine-protein kinase receptor. It contains a cytoplasmic tyrosine kinase domain, distally located serine-threonine-rich domains, an extracellular immunoglobulin-like domain, a cysteine-rich domain and a kringle domain. ROR2 is important for skeletal and endocrine development and is required for cartilage and growth plate development. It promotes the differentiation of osteoblasts and plays an important role in the early formation of chondrocytes. ROR2 sequesters and associates with Dlxin-1 affecting the transcriptional function of Msx-2. ROR2 also interacts with canoncial Wnt-1 and Wnt-3, regulating their signaling pathways. Defects in ROR2 can result in the autosomal dominant skeletal disorder, brachydactyly type B1, or the autosomal recessive skeletal disorder, Robinow syndrome.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Human cultured keratinocytes

Clone: ROR2-1911

Isotype: IgG

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: Human breast, pancreas, kidney or GIST.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for ROR2

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Alternative Name: ROR2 (ROR2 Products)

Synonyms: BDB antibody, BDB1 antibody, NTRKR2 antibody, Ntrkr2 antibody, mRor2 antibody, ROR2 antibody, bdb antibody, bdb1 antibody, Xror2 antibody, ntrkr2 antibody, MGC97773 antibody, LOC100219935 antibody, ror2 antibody, xror2 antibody, receptor tyrosine kinase like orphan receptor 2 antibody, receptor tyrosine kinase-like orphan receptor 2 antibody, receptor tyrosine kinase like orphan receptor 2 L homeolog antibody, ROR2 antibody, Ror2 antibody, ror2 antibody, ror2.L antibody

Background: BR, CD49 antigen-like family member B, ROR2, Collagen receptor, DX5, Glycoprotein Ia deficiency included (GPIa), Human platelet alloantigen system 5 (HPA5 included), Integrin alpha II (ITGA2), Platelet alloantigen Br(a), included, Platelet glycoprotein Ia/IIa, Platelet membrane glycoprotein Ia, VLA2,ROR2
Cellular localisation: Cell membrane.

Molecular Weight: 120kDa

Gene ID: 4920, 644776, 98255

UniProt: Q01974

Pathways: RTK Signaling, WNT Signaling