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FLT3 antibody

FLT3 Reactivity: Human IHC, StM Host: Mouse Monoclonal FLT3-2458 unconjugated
Catalog No. ABIN6939406
  • Target See all FLT3 Antibodies
    FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
    Reactivity
    • 141
    • 54
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 144
    • 13
    • 2
    • 1
    Mouse
    Clonality
    • 145
    • 15
    Monoclonal
    Conjugate
    • 67
    • 12
    • 10
    • 8
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    This FLT3 antibody is un-conjugated
    Application
    • 114
    • 69
    • 42
    • 42
    • 31
    • 21
    • 18
    • 12
    • 8
    • 8
    • 4
    • 3
    • 2
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Specificity
    Stem cell tyrosine kinase (STK-1) has been cloned from a CD34+ hematopoietic stem cell enriched library and identified as the human homolog of a previously identified gene of Mouse origin designated either Flk-2 or Flt-3. The STK-1 cDNA encodes a protein of 993 amino acids with 85 % identity to Flt-3/Flk-2. STK-1 is a member of the type III receptor tyrosine kinase family that includes Kit (steel factor receptor), Fms and PDGF. STK-1 expression in blood and marrow is restricted to CD34+ cells, a population greatly enriched for hematopoietic stem/progenitor cells. STK-1 antiserum recognizes two polypeptides in these cells. The Mouse homolog of STK-1, designated Flt-3/Flk-2, is expressed at high levels in hematopoietic cells and also in neural, gonadal, hepatic and placental tissues. It has been suggested that STK-1 and its murine homolog Flt-3/Flk-2 may function as growth factor receptors on hematopoietic stem and/or progenitor cells.
    Purification
    Purified by Protein A/G
    Immunogen
    Recombinant full-length human FLT3 protein
    Clone
    FLT3-2458
    Isotype
    IgG2b kappa
    Top Product
    Discover our top product FLT3 Primary Antibody
  • Application Notes

    Positive Control: Human lymph node or MDAMB468 xenograft.

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))
    Alternative Name
    FLT3 (FLT3 Products)
    Synonyms
    FLT3 antibody, B230315G04 antibody, CD135 antibody, Flk-2 antibody, Flk2 antibody, Flt-3 antibody, Ly72 antibody, wmfl antibody, FLK-2 antibody, FLK2 antibody, STK1 antibody, fms related tyrosine kinase 3 antibody, FMS-like tyrosine kinase 3 antibody, fms-related tyrosine kinase 3 antibody, FLT3 antibody, Flt3 antibody
    Molecular Weight
    160kDa
    Gene ID
    2322
    UniProt
    P36888
    Pathways
    RTK Signaling
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