CDK7 antibody (pThr170) (AbBy Fluor® 647)

Catalog No. ABIN6979826

Product Details anti-CDK7 Antibody (AbBy Fluor® 647)

Target: CDK7 (Cyclin-Dependent Kinase 7 (CDK7))

Binding Specificity: pThr170

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK7 antibody is conjugated to AbBy Fluor® 647

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated Synthesised phosphopeptide derived from human CDK7 around the phosphorylation site of Thr170

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CDK7

Target: CDK7 (Cyclin-Dependent Kinase 7 (CDK7))

Alternative Name: CDK7 (CDK7 Products)

Synonyms: CAK1 antibody, CDKN7 antibody, HCAK antibody, MO15 antibody, STK1 antibody, p39MO15 antibody, AI323415 antibody, AI528512 antibody, C230069N13 antibody, Cdkn7 antibody, Crk4 antibody, CD 7 antibody, CDK7 antibody, CG3319 antibody, DmCDK7 antibody, DmCdk7 antibody, DmMO15 antibody, DmMo15 antibody, Dmcdk7 antibody, Dmel\\CG3319 antibody, Mo15 antibody, cdk-7 antibody, cdk7 antibody, dCdk7 antibody, p40[MO15] antibody, p40MO15 antibody, stk1 antibody, zgc:85821 antibody, cak1 antibody, cdkn7 antibody, p39mo15 antibody, cyclin dependent kinase 7 antibody, cyclin-dependent kinase 7 antibody, Cyclin-dependent kinase 7 antibody, cyclin-dependent kinase 7 L homeolog antibody, CDK7 antibody, Cdk7 antibody, cdk7.L antibody, cdk7 antibody

Background:

Synonyms: CDK7 (phospho Thr170), CDK7 (phospho T170), Cyclin H, MAT1, Cyclin Dependent Kinase 7, CAK1, MO15, CDKN7, serine/threonine kinase, STK1, serine/threonine protein kinase 1, MO15 homolog,Xenopus laevis, cdk-activating kinase, Cdk-activating kinase, serine/threonine protein kinase MO15, homolog of Xenopus MO15 Cdk-activating kinase, kinase subunit of CAK, 39 KDa protein kinase, CR4 protein kinase, CRK4, CDK7_HUMAN.

Background: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.

Gene ID: 1022

UniProt: P50613

Pathways: Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, M Phase