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IRAK1 antibody (AA 618-712)

IRAK1 Reactivity: Human, Mouse WB, ELISA, IHC (p) Host: Mouse Monoclonal 8F1A7 unconjugated
Catalog No. ABIN6990202
  • Target See all IRAK1 Antibodies
    IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))
    Binding Specificity
    • 31
    • 19
    • 18
    • 16
    • 10
    • 8
    • 8
    • 6
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 618-712
    Reactivity
    • 142
    • 85
    • 62
    • 2
    • 1
    • 1
    Human, Mouse
    Host
    • 142
    • 12
    • 2
    Mouse
    Clonality
    • 145
    • 11
    Monoclonal
    Conjugate
    • 62
    • 8
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    This IRAK1 antibody is un-conjugated
    Application
    • 113
    • 69
    • 65
    • 54
    • 52
    • 24
    • 17
    • 14
    • 13
    • 11
    • 7
    • 4
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    IRAK Monoclonal Antibody is Protein G purified.
    Immunogen
    Recombinant protein corresponding to amino acids 618 - 712 of human IRAK.
    Clone
    8F1A7
    Isotype
    IgG1
    Top Product
    Discover our top product IRAK1 Primary Antibody
  • Application Notes
    IRAK antibody can be used for Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

    Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    IRAK Monoclonal Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    IRAK monoclonal antibody can be stored at -20°C, stable for one year.
  • Target
    IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))
    Alternative Name
    IRAK (IRAK1 Products)
    Synonyms
    IRAK1 antibody, IRAK antibody, pelle antibody, AA408924 antibody, IRAK-1 antibody, IRAK1-S antibody, Il1rak antibody, Plpk antibody, mPLK antibody, RGD1563841 antibody, interleukin 1 receptor associated kinase 1 antibody, interleukin-1 receptor-associated kinase 1 antibody, IRAK1 antibody, irak1 antibody, Irak1 antibody
    Background
    IRAK Monoclonal Antibody: Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ,B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-κ,B activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).
    Gene ID
    3654
    UniProt
    P51617
    Pathways
    NF-kappaB Signaling, TLR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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