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SCO1 antibody (AA 100-150)

SCO1 Reactivity: Human, Mouse, Rat WB, ELISA, IF, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6990717
  • Target See all SCO1 Antibodies
    SCO1 (SCO1 Cytochrome C Oxidase Assembly Protein (SCO1))
    Binding Specificity
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 100-150
    Reactivity
    • 15
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 12
    • 3
    Rabbit
    Clonality
    • 15
    Polyclonal
    Conjugate
    • 11
    • 2
    • 1
    • 1
    This SCO1 antibody is un-conjugated
    Application
    • 10
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    SCO1 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    SCO1 antibody was raised against a 14 amino acid synthetic peptide from near the center of human SCO1. The immunogen is located within amino acids 100 - 150 of SCO1.
    Isotype
    IgG
    Top Product
    Discover our top product SCO1 Primary Antibody
  • Application Notes
    SCO1 antibody can be used for detection of SCO1 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    SCO1 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    SCO1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    SCO1 (SCO1 Cytochrome C Oxidase Assembly Protein (SCO1))
    Alternative Name
    SCO1 (SCO1 Products)
    Synonyms
    SCOD1 antibody, 2610001C07Rik antibody, D11Bwg1310e antibody, SCO1 antibody, RGD1559538 antibody, SCO1, cytochrome c oxidase assembly protein antibody, SCO1 cytochrome c oxidase assembly protein antibody, SCO1 antibody, Sco1 antibody, sco1 antibody
    Background
    SCO1 Antibody: Synthesis of cytochrome c oxidase 1 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO1 and SCO2 are dependent on copper ion binding. Mutations in either gene can lead to cytochrome c oxidase respiratory chain defects, with a missense mutation in human SCO1 (P174L) associated with a fatal neonatal hepatopathy when the second allele is also non-functional, suggesting the pathology is due to loss of function. It has been suggested that this mutation alters the SCO1 affinity for the copper (I) ion, thus impairing the efficiency of copper transfer to the cytochrome c oxidase. At least two isoforms of SCO1 are known to exist and both are recognized by the SCO1 antibody. This SCO1 antibody has no cross-reactivity to SCO2.
    Gene ID
    6341
    UniProt
    O75880
    Pathways
    Sensory Perception of Sound, Transition Metal Ion Homeostasis, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity
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