MAGE-Like 2 antibody

Catalog No. ABIN7239188

Product Details anti-MAGE-Like 2 Antibody

Target: MAGE-Like 2 (MAGEL2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAGE-Like 2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Synthetic peptide of human MAGEL2

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.8 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MAGE-Like 2

Target: MAGE-Like 2 (MAGEL2)

Alternative Name: MAGEL2 (MAGEL2 Products)

Synonyms: NDNL1 antibody, nM15 antibody, MAGEL2 antibody, Mage-l2 antibody, ns7 antibody, MAGE family member L2 antibody, melanoma antigen, family L, 2 antibody, MAGEL2 antibody, Magel2 antibody

Background: Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS.

NCBI Accession: NP_061939

UniProt: Q9UJ55