PKD1 antibody

Catalog No. ABIN7075124

Product Details anti-PKD1 Antibody

Target: PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKD1 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse Polycystin 1

Application Details

Application Notes: WB (H) 1: 500-1: 1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for PKD1

Target: PKD1 (Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))

Alternative Name: Polycystin 1 (PKD1 Products)

Synonyms: PBP antibody, Pc-1 antibody, TRPP1 antibody, PC1 antibody, mFLJ00285 antibody, polycystin 1, transient receptor potential channel interacting antibody, polycystin 1, transient receptor poteintial channel interacting antibody, polycystin-1 antibody, PKD1 antibody, Pkd1 antibody, LOC749291 antibody

Background: This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. Involved in renal tubulo genesis. Involved in fluid-flow mechano sensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene.

Molecular Weight: >460 kDa

Gene ID: 18763

NCBI Accession: NP_038658

UniProt: O08852

Pathways: Myometrial Relaxation and Contraction, Maintenance of Protein Location