HTR2A antibody (AA 21-120) (Alexa Fluor 647)

Catalog No. ABIN7090714

Product Details anti-HTR2A Antibody (Alexa Fluor 647)

Target: HTR2A (5-Hydroxytryptamine (serotonin) Receptor 2A (HTR2A))

Binding Specificity: AA 21-120

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HTR2A antibody is conjugated to Alexa Fluor 647

Application: Immunofluorescence (Cultured Cells) (IF (cc))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human 5HT2A Receptor

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Target Details for HTR2A

Target: HTR2A (5-Hydroxytryptamine (serotonin) Receptor 2A (HTR2A))

Alternative Name: 5HT2A Receptor (HTR2A Products)

Synonyms: 5-HT2A antibody, HTR2 antibody, 5-HT-2 antibody, 5-HT-2A antibody, 5-HTR2A antibody, LOC100009461 antibody, E030013E04 antibody, Htr-2 antibody, Htr2 antibody, 5Ht-2 antibody, 5HT2A antibody, 5HTR2A antibody, HTR2A antibody, Htr2a antibody, 5HT2 antibody, 5-hydroxytryptamine receptor 2A antibody, 5-hydroxytryptamine (serotonin) receptor 2A antibody, HTR2A antibody, Htr2a antibody

Background:

Synonyms: 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor, Serotonin receptor 2A, 5-HT-2A, 5-HT-2, HTR2A, Htr2a, 5 HT 2, 5HTR2A, 5 HT 2A, 5 HT2 receptor, 5 HT2A, 5 hydroxytryptamine receptor 2A, 5-HT-2, 5-HT-2A, 5-hydroxytryptamine 2A receptor, 5-hydroxytryptamine receptor 2A, 5HT2A_HUMAN, HTR 2, HTR 2A, HTR2, HTR2A

Background: G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca2+ ions from intracellular stores (PubMed:18703043, PubMed:28129538). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.

Gene ID: 3356

UniProt: P28223

Pathways: JAK-STAT Signaling, Inositol Metabolic Process, Regulation of Carbohydrate Metabolic Process