AATF antibody

Catalog No. ABIN7111679

Product Details anti-AATF Antibody

Target: AATF (Apoptosis Antagonizing Transcription Factor (AATF))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AATF antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: apoptosis antagonizing transcription factor

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:2000, IF: 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for AATF

Target: AATF (Apoptosis Antagonizing Transcription Factor (AATF))

Alternative Name: AATF (AATF Products)

Synonyms: AATF antibody, ded antibody, che1 antibody, che-1 antibody, cb109 antibody, sb:cb109 antibody, wu:fc13d05 antibody, zgc:162071 antibody, CHE-1 antibody, CHE1 antibody, DED antibody, 4933415H02Rik antibody, 5830465M17Rik antibody, Che-1 antibody, Trb antibody, Ded antibody, apoptosis antagonizing transcription factor antibody, Apoptosis antagonizing transcription factor antibody, apoptosis antagonizing transcription factor S homeolog antibody, AATF antibody, aatf antibody, BFR2 antibody, NAEGRDRAFT_56916 antibody, Aatf antibody, aatf.S antibody

Background: Synonyms:AATF, CHE 1, CHE1, DED, Protein AATF, Rb binding protein Che 1, Traube Background:May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease(presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

Molecular Weight: 63 kDa

Gene ID: 26574

UniProt: Q9NY61

Pathways: Neurotrophin Signaling Pathway, SARS-CoV-2 Protein Interactome