EIF2AK2 antibody (pThr446)
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- Target See all EIF2AK2 Antibodies
- EIF2AK2 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))
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Binding Specificity
- pThr446
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This EIF2AK2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
- Cross-Reactivity
- Human, Mouse
- Purification
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
- Immunogen
- Peptide sequence around phosphorylation site of threonine 446 (K-R-T(p)-R-S) derived from Human PKR.
- Isotype
- IgG
- Top Product
- Discover our top product EIF2AK2 Primary Antibody
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- Application Notes
- WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- EIF2AK2 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))
- Alternative Name
- EIF2AK2 (EIF2AK2 Products)
- Synonyms
- PKR antibody, pkr antibody, EIF2AK2 antibody, DKFZp469K1934 antibody, EIF2AK1 antibody, PRKR antibody, 2310047A08Rik antibody, 4732414G15Rik antibody, AI467567 antibody, AI747578 antibody, Pkr antibody, Prkr antibody, Tik antibody, eukaryotic translation initiation factor 2 alpha kinase 2 antibody, eukaryotic translation initiation factor 2-alpha kinase 2 antibody, EIF2AK2 antibody, eif2ak2 antibody, Eif2ak2 antibody
- Background
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Background:
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.
Abujiang Pataer, et,al. (2002) Cancer Res, 62: 2239.
K. D. Ryman, et,al. (2005) J. Virol, 79: 1487 - 1499.
Susana Guerra, et,al. (2006) J. Biol. Chem, 281: 18734 - 18745.Aliases: Double stranded RNA activated protein kinase antibody, E2AK2_HUMAN antibody, eIF-2A protein kinase 2 antibody, EIF2AK1 antibody, EIF2AK2 antibody, Eukaryotic translation initiation factor 2 alpha kinase 2 antibody, Eukaryotic translation initiation factor 2-alpha kinase 2 antibody, HGNC:9437 antibody, Interferon induced double stranded RNA activated protein kinase antibody, Interferon inducible elF2 alpha kinase antibody, Interferon inducible RNA dependent protein kinase antibody, Interferon-induced, double-stranded RNA-activated protein kinase antibody, Interferon-inducible RNA-dependent protein kinase antibody, MGC126524 antibody, P1/eIF-2A protein kinase antibody, P1/eIF2A protein kinase antibody, p68 kinase antibody, PKR antibody, PPP1R83 antibody, PRKR antibody, Protein kinase interferon inducible double stranded RNA dependent antibody, Protein kinase RNA activated antibody, Protein kinase RNA-activated antibody, Protein phosphatase 1 regulatory subunit 83 antibody, Serine/threonine protein kinase TIK antibody, Tyrosine protein kinase EIF2AK2 antibody
- UniProt
- P19525
- Pathways
- DNA Damage Repair, ER-Nucleus Signaling, Hepatitis C
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