ROS1 antibody (AA 1-320) (HRP)

Catalog No. ABIN7140568

Product Details anti-ROS1 Antibody (HRP)

Target: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Binding Specificity: AA 1-320

Reactivity: Arabidopsis thaliana

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ROS1 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Arabidopsis thaliana

Purification: >95%, Protein G purified

Immunogen: Recombinant Arabidopsis thaliana Protein ROS1 protein (1-320AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ROS1

Target: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Alternative Name: ROS1 (ROS1 Products)

Synonyms: MCF3 antibody, ROS antibody, c-ros-1 antibody, ROS1C antibody, Ros-1 antibody, c-ros antibody, ROS proto-oncogene 1, receptor tyrosine kinase antibody, ROS proto-oncogene 1 , receptor tyrosine kinase antibody, Ros1 proto-oncogene antibody, ROS1 antibody, Ros1 antibody

Background:

Background: Bifunctional DNA glycosylase/lyase, which excises 5-methylcytosine (5-meC) and 5-hydroxymethylcytosine (5-hmeC), leaving an apyrimidinic (AP) site that is subsequently incised by the lyase activity (PubMed:25240767). Generates 3\'-phosphor-alpha,beta-unsaturated aldehyde (3\'-PUA) as a primary 5-meC excision intermediate (PubMed:25228464). Prevents DNA hypermethylation, specifically in the promoter of otherwise silenced loci. May be involved in DNA repair through its nicking activity on methylated DNA. Binds with similar affinity to both methylated and non-methylated DNA. Highly distributive behavior on DNA substrates containing multiple 5-meC residues. Involved with Pol IV in the remodeling of the 5S rDNA chromatin via DNA methylation modifications during the first days of development post-germination. Participates in UV-B induced- and oxidative DNA damage repair (PubMed:24155752).

Aliases: ROS1 antibody, DML1 antibody, At2g36490 antibody, F1O11.12 antibody, DNA glycosylase/AP lyase ROS1 antibody, EC 4.2.99.18 antibody, DEMETER-like protein 1 antibody, Protein REPRESSOR OF SILENCING 1 antibody, Protein ROS1 antibody

UniProt: Q9SJQ6

Pathways: RTK Signaling