CACNA1D antibody (AA 1201-1300) (Cy3)

Catalog No. ABIN751336

This Rabbit Polyclonal antibody specifically detects CACNA1D in IF (p) and IF (cc). It exhibits reactivity toward Rat and Monkey.

Quick Overview for CACNA1D antibody (AA 1201-1300) (Cy3) (ABIN751336)

Target: CACNA1D (Calcium Channel, Voltage-Dependent, L Type, alpha 1D Subunit (CACNA1D))

Reactivity: Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CACNA1D antibody is conjugated to Cy3

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Product Details anti-CACNA1D Antibody (Cy3)

Binding Specificity: AA 1201-1300

Cross-Reactivity: Monkey, Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CaV1.3

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CACNA1D

Target: CACNA1D (Calcium Channel, Voltage-Dependent, L Type, alpha 1D Subunit (CACNA1D))

Alternative Name: CACH3/CaV1.3

Background:

Synonyms: CACH3, CACN4, PASNA, SANDD, Cav1.3, CCHL1A2, CACNL1A2, Voltage-dependent L-type calcium channel subunit alpha-1D, Calcium channel, L type, alpha-1 polypeptide, isoform 2, Voltage-gated calcium channel subunit alpha Cav1.3, CACNA1D

Background: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).

Gene ID: 776

UniProt: Q01668

Pathways: Sensory Perception of Sound