ERP44 antibody (Internal Region)

Catalog No. ABIN784030

Product Details anti-ERP44 Antibody

Target: ERP44 (Endoplasmic Reticulum Protein 44 (ERP44))

Binding Specificity: Internal Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERP44 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody reacts to the internal region of ERP44 / TXNDC4.

Purification: Immunoaffinity chromatography

Immunogen: ERP44 antibody was raised against internal domain of human.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: PBS containing 0.09 % sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ERP44

Target: ERP44 (Endoplasmic Reticulum Protein 44 (ERP44))

Alternative Name: TXNDC4 / ERP44 (ERP44 Products)

Synonyms: PDIA10 antibody, TXNDC4 antibody, 1110001E24Rik antibody, AI849526 antibody, AL033348 antibody, Txndc4 antibody, BWK4 antibody, txndc4 antibody, zgc:77883 antibody, endoplasmic reticulum protein 44 antibody, ERP44 antibody, Erp44 antibody, erp44 antibody

Background: TXNDC4/ERp44/KIAA0573 was identified via its interaction with Erol-Lalpha, which in turn has been shown to regulate oxidative protein folding by selectively oxidizing protein disulfide isomerase. TXNDC4 is induced during ER stress and forms mixed disulfides with both hEROs and cargo folding intermediates. Over expression has been shown to alter the equilibrium of the different Ero1-Lalpha redox isoforms suggesting that TXNDC4 may be involved in the control of oxidative protein folding. It has also been suggested that TXNDC4 senses the environment in the ER lumen because it modulates IP3R1 (1,4,5-triphosphate receptor type 1) activity thereby regulating cytosolic calcium concentrations and intraluminal conditions.Synonyms: Endoplasmic reticulum resident protein ERp44, KIAA0573, Thioredoxin domain-containing protein 4

Gene ID: 23071

NCBI Accession: NP_055866

Pathways: Cell RedoxHomeostasis, SARS-CoV-2 Protein Interactome