Endoplasmic Reticulum Protein 44 (ERP44) (Internal Region) antibody

Details for Product No. ABIN784030
Target
Binding Specificity
Internal Region
11
4
3
2
2
1
1
1
1
Reactivity
Human
39
7
6
3
3
3
3
3
3
3
2
2
2
2
1
1
1
Host
Rabbit
25
8
7
Clonality
Polyclonal
Conjugate
Un-conjugated
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
27
18
11
10
8
3
1
1
1
Options
Immunogen ERP44 antibody was raised against internal domain of human.
Specificity This antibody reacts to the internal region of ERP44 / TXNDC4.
Purification Immunoaffinity chromatography
Target
Alternative Name TXNDC4 / ERP44 (ERP44 Antibody Abstract)
Background TXNDC4/ERp44/KIAA0573 was identified via its interaction with Erol-Lalpha, which in turn has been shown to regulate oxidative protein folding by selectively oxidizing protein disulfide isomerase. TXNDC4 is induced during ER stress and forms mixed disulfides with both hEROs and cargo folding intermediates. Over expression has been shown to alter the equilibrium of the different Ero1-Lalpha redox isoforms suggesting that TXNDC4 may be involved in the control of oxidative protein folding. It has also been suggested that TXNDC4 senses the environment in the ER lumen because it modulates IP3R1 (1,4,5-triphosphate receptor type 1) activity thereby regulating cytosolic calcium concentrations and intraluminal conditions.Synonyms: Endoplasmic reticulum resident protein ERp44, KIAA0573, Thioredoxin domain-containing protein 4
Gene ID 23071
NCBI Accession NP_055866
Pathways Cell RedoxHomeostasis, SARS-CoV-2 Protein Interactome
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1,0 mg/mL
Buffer PBS containing 0.09 % sodium azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Images
Image no. 1 for anti-Endoplasmic Reticulum Protein 44 (ERP44) (Internal Region) antibody (ABIN784030) Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Image no. 2 for anti-Endoplasmic Reticulum Protein 44 (ERP44) (Internal Region) antibody (ABIN784030) Stomach: Formalin-Fixed, Paraffin-Embedded (FFPE)