|Antigen||Caspase 1 (CASP1) Antibodies|
|Epitope||AA 47-168 Alternatives|
|Reactivity||Dog (Canine), Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This Caspase 1 antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Western Blotting (WB)
|3 references available|
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Product Details anti-Caspase 1 AntibodyTarget Details Caspase 1 Application Details Handling References for anti-Caspase 1 antibody (ABIN968350) Images
|Cross-Reactivity||Dog (Canine), Mouse (Murine), Rat (Rattus)|
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Immunogen||Human p45/SUG1 aa. 47-168|
Target Details Caspase 1Product Details anti-Caspase 1 Antibody Application Details Handling References for anti-Caspase 1 antibody (ABIN968350) Images back to top
|Alternative Name||p45 (CASP1 Antibody Abstract)|
The 26S proteasome, a eukaryotic ATP-dependent protease complex, is responsible for selective degradation of malformed proteins and certain short-lived proteins. The 26S proteasome complex consists of the 20S proteasome (multifunctional protease), which is the catalytic core, and an ATPase-containing P700 regulatory complex. This complex contains five highly related putative ATPases (TBP1, TBP7, S4, MSS1, p45) that belong to the ATPase family designated AAA (ATPases Associated with a variety of cellular Activities). They share a highly conserved 200 amino acid ATPase domain (AAA module) and participate in a range of cellular functions. p45 (Trip1, hSUG1) is the homolog of the S. cerevisiae and mouse SUG1 proteins. In a ligand-enhanced manner, mouse SUG1 interacts with a range of nuclear receptors via their AF-2 domains and yeast SUG1 functions as a transcription factor that mediates the transcriptional response of the GAL4 protein. p45 is thought to be their functional homolog. Thus, in addition to its participation in the P700 regulatory complex, p45 may function as a mammalian transcriptional modulator.
|Molecular Weight||45 kDa|
|Pathways||Apoptosis, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity|
Application DetailsProduct Details anti-Caspase 1 Antibody Target Details Caspase 1 Handling References for anti-Caspase 1 antibody (ABIN968350) Images back to top
Related Products: ABIN967389, ABIN968587
|Restrictions||For Research Use only|
HandlingProduct Details anti-Caspase 1 Antibody Target Details Caspase 1 Application Details References for anti-Caspase 1 antibody (ABIN968350) Images back to top
|Buffer||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at -20°C.|
References for anti-Caspase 1 antibody (ABIN968350)Product Details anti-Caspase 1 Antibody Target Details Caspase 1 Application Details Handling Images back to top
|Product cited in:||
Fraser, Rossignol, Heard, Egly, Chambon: "SUG1, a putative transcriptional mediator and subunit of the PA700 proteasome regulatory complex, is a DNA helicase." in: The Journal of biological chemistry, Vol. 272, Issue 11, pp. 7122-6, 1997
Makino, Yogosawa, Kanemaki, Yoshida, Yamano, Kishimoto, Moncollin, Egly, Muramatsu, Tamura: "Structures of the rat proteasomal ATPases: determination of highly conserved structural motifs and rules for their spacing." in: Biochemical and biophysical research communications, Vol. 220, Issue 3, pp. 1049-54, 1996
Akiyama, Yokota, Kagawa, Shimbara, DeMartino, Slaughter, Noda, Tanaka: "cDNA cloning of a new putative ATPase subunit p45 of the human 26S proteasome, a homolog of yeast transcriptional factor Sug1p." in: FEBS letters, Vol. 363, Issue 1-2, pp. 151-6, 1995
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