anti-Human Caspase 1 antibody for Immunohistochemistry

Recommended Caspase 1 Antibody (supplied by: Log in to see )

Antigen
Caspase 1 (CASP1) Antibodies
  • ICE
  • IL1BC
  • P45
  • Il1bc
  • Ice
  • CASP1
  • CG5370
  • DCP-1
  • DCP1
  • Dcp1
  • Dmel\\CG5370
  • ccp1
  • dcp-1
  • dcp1
  • l(2)01862
  • l(2)02132
  • caspase 1
  • caspase 1, apoptosis-related cysteine peptidase
  • caspase 4, apoptosis-related cysteine peptidase
  • Death caspase-1
  • caspase-1
  • caspase
  • caspase recruitment domain-containing protein 16
  • caspase 4
  • CASP1
  • Casp1
  • CASP4
  • Dcp-1
  • Caspase1
  • LOC5564196
  • LOC451519
Epitope
AA 1-100
35
16
12
11
10
10
9
9
7
7
6
5
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
258
96
75
8
2
2
2
1
1
1
1
1
1
Host
Mouse
250
36
8
2
Clonality
Monoclonal
Conjugate
This Caspase 1 antibody is un-conjugated
23
16
8
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
266
160
117
76
32
26
18
15
7
5
3
3
1
Options
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Catalog No. ABIN393212
$ 461.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
15.850119 ABIN3183664 ELISA IHC WB Rabbit IgG Ser197 Log in to see Polyclonal 0
15.850119 ABIN3181758 ELISA IHC WB Rabbit IgG Asp210, cleaved Log in to see Polyclonal 0
15.850119 ABIN3021171 IHC WB Rabbit IgG Log in to see Polyclonal 0
13.039878 ABIN461890 ELISA IHC IHC (p) WB Rabbit IgG C-Term Log in to see Polyclonal 0
13.039878 ABIN6260470 ELISA ICC IF IHC WB Rabbit IgG Log in to see Polyclonal 0
13.039878 ABIN461892 ELISA IHC IHC (p) WB Rabbit IgG Log in to see Polyclonal 0
12.850119 ABIN3182631 ELISA IHC WB Rabbit IgG pSer376 Log in to see Polyclonal 0
12.850119 ABIN3181759 ELISA IHC Rabbit IgG Met211, cleaved Log in to see Polyclonal 0
12.850119 ABIN5617521 ELISA IHC WB Rabbit IgG Ser376 Log in to see Polyclonal 0
12.850119 ABIN5619047 IHC WB Rabbit Center Log in to see Polyclonal 0
12.850119 ABIN5619046 IHC IP WB Rabbit C-Term Log in to see Polyclonal 0
12.850119 ABIN5619048 IHC WB Rabbit Center Log in to see Polyclonal 0
12.850119 ABIN2135441 IHC ELISA WB Rabbit IgG Asp210 Log in to see Polyclonal 0
12.850119 ABIN2135442 IHC ELISA Rabbit IgG Asp210 Log in to see Polyclonal 0
12.850119 ABIN2135444 IHC ELISA WB Rabbit IgG pSer376 Log in to see Polyclonal 0
12.850119 ABIN2135436 IHC ELISA WB Biotin Rabbit IgG Log in to see Polyclonal 0
12.850119 ABIN2135434 IHC ELISA WB HRP Rabbit IgG Log in to see Polyclonal 0
12.850119 ABIN2135435 IHC ELISA WB FITC Rabbit IgG Log in to see Polyclonal 0
12.850119 ABIN2135440 IHC ELISA WB Rabbit IgG Log in to see Polyclonal 0
10.039878 ABIN1531644 IHC ELISA WB Rabbit IgG AA 342-391, pSer376 Log in to see Polyclonal 3

General

Antigen Caspase 1 (CASP1) Antibodies
Epitope AA 1-100
(35), (16), (12), (11), (10), (10), (9), (9), (7), (7), (6), (5), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(258), (96), (75), (8), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Host Mouse
(250), (36), (8), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Caspase 1 antibody is un-conjugated
(23), (16), (8), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
(266), (160), (117), (76), (32), (26), (18), (15), (7), (5), (3), (3), (1)
Pubmed 5 references available
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Product Details anti-Caspase 1 Antibody

Target Details Caspase 1 Application Details Handling References for anti-Caspase 1 antibody (ABIN393212) Images
Specificity CASP1 (AAH62327, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Cross-Reactivity (Details) Human: ~~ Positive
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Immunogen

Antigen Type: Recombinant Protein

Target/Specificity: CASP1 (AAH62327, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone 3D2
Isotype IgG2a kappa
Plasmids, Primers & others

Target Details Caspase 1

Product Details anti-Caspase 1 Antibody Application Details Handling References for anti-Caspase 1 antibody (ABIN393212) Images back to top
Antigen
Alternative Name CASP1 (CASP1 Antibody Abstract)
Background

Other Names: Caspase-1, CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme, p45, Caspase-1 subunit p20, Caspase-1 subunit p10, CASP1, IL1BC, IL1BCE

Gene Description: caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)

Gene Summary: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq

Molecular Weight 45159 DA
Gene ID 834
NCBI Accession NP_001214, NP_001244047, NP_001244048, NP_150634, NP_150635, NP_150636, NP_150637
UniProt P29466
Pathways Apoptosis, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity

Application Details

Product Details anti-Caspase 1 Antibody Target Details Caspase 1 Handling References for anti-Caspase 1 antibody (ABIN393212) Images back to top
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml
Comment

Background: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms.

Restrictions For Research Use only

Handling

Product Details anti-Caspase 1 Antibody Target Details Caspase 1 Application Details References for anti-Caspase 1 antibody (ABIN393212) Images back to top
Buffer Clear, colorless solution in phosphate buffered saline,  pH 7.2 .
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months

References for anti-Caspase 1 antibody (ABIN393212)

Product Details anti-Caspase 1 Antibody Target Details Caspase 1 Application Details Handling Images back to top
Background publications

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010

Schuurhof, Bont, Siezen, Hodemaekers, van Houwelingen, Kimman, Hoebee, Kimpen, Janssen: "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls." in: Pediatric pulmonology, Vol. 45, Issue 6, pp. 608-13, 2010

Wang, Fu, Xie, Wang, Chu, Wang, Shen, Wang, Wang, Sun, Lei, Yang, Wu, Foo, Liu, Jin, Huang: "Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population." in: Journal of human genetics, Vol. 55, Issue 8, pp. 490-4, 2010

Kim, Park, Kim, Lee, Lim, Song, Yoo, Lee: "Mutational analysis of caspase genes in prostate carcinomas." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 118, Issue 4, pp. 308-12, 2010

Weigert, Cremer, Schmidt, von Knethen, Angioni, Geisslinger, Brüne: "Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells." in: Blood, Vol. 115, Issue 17, pp. 3531-40, 2010

Images

Product Details anti-Caspase 1 Antibody Target Details Caspase 1 Application Details Handling References for anti-Caspase 1 antibody (ABIN393212) back to top
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Caspase 1 (CASP1) (AA 1-100) antibody (ABIN393212) Immunoperoxidase of monoclonal antibody to CASP1 on formalin-fixed paraffin-embedded ...
Immunohistochemistry (IHC) image for anti-Caspase 1 (CASP1) (AA 1-100) antibody (ABIN393212) anti-Caspase 1 (CASP1) (AA 1-100) antibody (Image 2)
Western Blotting (WB) image for anti-Caspase 1 (CASP1) (AA 1-100) antibody (ABIN393212) Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunoge...
Immunohistochemistry (IHC) image for anti-Caspase 1 (CASP1) (AA 1-100) antibody (ABIN393212) Immunoperoxidase of monoclonal antibody to CASP1 on formalin-fixed paraffin-embedded ...
ELISA image for anti-Caspase 1 (CASP1) (AA 1-100) antibody (ABIN393212) Detection limit for recombinant GST tagged CASP1 is approximately 0.1ng/ml as a captu...