anti-Mouse (Murine) Caspase 1 antibody for Western Blotting

Recommended Caspase 1 Antibody (supplied by: Log in to see )

Antigen
Caspase 1 (CASP1) Antibodies
  • ICE
  • IL1BC
  • P45
  • Il1bc
  • Ice
  • CASP1
  • CG5370
  • DCP-1
  • DCP1
  • Dcp1
  • Dmel\\CG5370
  • ccp1
  • dcp-1
  • dcp1
  • l(2)01862
  • l(2)02132
  • caspase 1
  • caspase 1, apoptosis-related cysteine peptidase
  • caspase 4, apoptosis-related cysteine peptidase
  • Death caspase-1
  • caspase-1
  • caspase
  • caspase recruitment domain-containing protein 16
  • caspase 4
  • CASP1
  • Casp1
  • CASP4
  • Dcp-1
  • Caspase1
  • LOC5564196
  • LOC451519
Epitope
AA 137-157, N-Term
35
16
12
11
10
9
9
9
7
7
6
5
4
4
4
3
3
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine), Rat (Rattus)
259
95
74
8
2
2
2
1
1
1
1
1
1
Host
Rabbit
249
37
8
2
Clonality
Polyclonal
Conjugate
This Caspase 1 antibody is un-conjugated
23
16
8
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
266
161
118
76
32
26
18
15
7
5
3
3
1
Options
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Catalog No. ABIN5518669
$ 240.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
16.392223 ABIN3183664 ELISA IHC WB Rabbit IgG Ser197 Log in to see Polyclonal 0
16.392223 ABIN3021171 IHC WB Rabbit IgG Log in to see Polyclonal 0
12.572235 ABIN3182631 ELISA IHC WB Rabbit IgG pSer376 Log in to see Polyclonal 0
10.819987 ABIN6255274 ELISA ICC IF WB Rabbit IgG pSer376 Log in to see Polyclonal 0
10.819987 ABIN6260479 ELISA ICC IF WB Rabbit IgG Log in to see Polyclonal 0
10.819987 ABIN6260470 ELISA ICC IF IHC WB Rabbit IgG Log in to see Polyclonal 0
10.819987 ABIN1077907 ICC IHC WB Rabbit IgG AA 119-296 Log in to see Polyclonal 0
10.819987 ABIN2902445 IF/ICC IHC IP WB Rabbit AA 119-296 Log in to see Polyclonal 0
9.319987 ABIN222877 IF IP WB Rabbit IgG Log in to see Polyclonal 5
7.819988 ABIN1532666 IHC ELISA WB Rabbit IgG AA 342-391 Log in to see Polyclonal 3
7.819988 ABIN1531644 IHC ELISA WB Rabbit IgG AA 342-391, pSer376 Log in to see Polyclonal 3
7.819988 ABIN2705671 IHC WB Rabbit Center Log in to see Polyclonal 0
7.819988 ABIN2427583 IHC ELISA WB Rabbit IgG Log in to see Polyclonal 0
7 ABIN2888870 ELISA IHC IHC (p) WB Rabbit IgG AA 342-391 Log in to see Polyclonal 0
7 ABIN1575259 IHC ELISA WB Rabbit IgG pSer376 Log in to see Polyclonal 0
4.819988 ABIN2654583 WB Rabbit IgG Log in to see Polyclonal 0
4.819988 ABIN5956042 ELISA IHC (p) WB Rabbit IgG Ser376 Log in to see Polyclonal 0
4.819988 ABIN2983815 WB Rabbit IgG Log in to see Polyclonal 0
4.819988 ABIN3030287 WB Rabbit IgG N-Term, Subunit p20 Log in to see Polyclonal 0
4.819988 ABIN187450 EIA FACS WB Rat IgG1 Log in to see 1H11 0

General

Antigen Caspase 1 (CASP1) Antibodies
Epitope AA 137-157, N-Term
(35), (16), (12), (11), (10), (9), (9), (9), (7), (7), (6), (5), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Mouse (Murine), Rat (Rattus)
(259), (95), (74), (8), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Host Rabbit
(249), (37), (8), (2)
Clonality
Polyclonal
Conjugate This Caspase 1 antibody is un-conjugated
(23), (16), (8), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Western Blotting (WB)
(266), (161), (118), (76), (32), (26), (18), (15), (7), (5), (3), (3), (1)
Pubmed 21 references available
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Product Details anti-Caspase 1 Antibody

Target Details Caspase 1 Application Details Handling References for anti-Caspase 1 antibody (ABIN5518669) Images
Purpose Rabbit IgG polyclonal antibody for Caspase-1(CASP1) detection. Tested with WB in Mouse,Rat.
Sequence LEKAQKLWKE NPSEIYPIMN T
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for Caspase-1(CASP1) detection. Tested with WB in Mouse,Rat.
Gene Name: caspase 1, apoptosis-related cysteine peptidase
Protein Name: Caspase-1
Purification Immunogen affinity purified.
Immunogen A synthetic peptide corresponding to a sequence at the N-terminus of mouse CASP1(137-157aa LEKAQKLWKENPSEIYPIMNT), different from the related rat sequence by three amino acids.
Isotype IgG
Plasmids, Primers & others

Target Details Caspase 1

Product Details anti-Caspase 1 Antibody Application Details Handling References for anti-Caspase 1 antibody (ABIN5518669) Images back to top
Antigen
Alternative Name CASP1 (CASP1 Antibody Abstract)
Background Caspase 1 is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta, IL18, and IL33 precursor proteins. It belongs to a family of cysteine proteases known as caspases that always cleave proteins following an aspartic acid residue. The Caspase1 gene consists of 10 exons spanning at least 10.6 kb. The Caspase 1 gene is mapped to 11q23, a site frequently involved in rearrangement in human cancers, including a number of leukemias and lymphomas, by Southern DNA blot analysis of rodent-human hybrids and by in situ hybridization to normal human metaphase chromosomes. Caspase 1 has been shown to induce cell necrosis or pyroptosis and may function in various developmental stages.

Synonyms: CASP 1 antibody|CASP-1 antibody|CASP1 antibody|Caspase 1 apoptosis related cysteine peptidase antibody|Caspase 1 apoptosis related cysteine protease antibody|Caspase-1 subunit p20 antibody|Caspase1 antibody|ICE antibody|IL 1 beta converting enzyme antibody|IL 1BC antibody|IL-1 beta-converting enzyme antibody|IL-1BC antibody|IL1 beta converting enzyme antibody|IL1B convertase antibody|IL1BC antibody|IL1BCE antibody|Interleukin 1 beta convertase antibody|Interleukin 1 beta convertase precursor antibody|Interleukin 1 beta converting enzyme antibody|Interleukin 1B converting enzyme antibody|Interleukin-1 beta convertase antibody|Interleukin-1 beta-converting enzyme antibody|P45 antibody
UniProt P29452
Pathways Apoptosis, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity

Application Details

Product Details anti-Caspase 1 Antibody Target Details Caspase 1 Handling References for anti-Caspase 1 antibody (ABIN5518669) Images back to top
Application Notes WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
Comment

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

Restrictions For Research Use only

Handling

Product Details anti-Caspase 1 Antibody Target Details Caspase 1 Application Details References for anti-Caspase 1 antibody (ABIN5518669) Images back to top
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Concentration 500 μg/mL
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative Sodium azide, Thimerosal (Merthiolate)
Precaution of Use This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

References for anti-Caspase 1 antibody (ABIN5518669)

Product Details anti-Caspase 1 Antibody Target Details Caspase 1 Application Details Handling Images back to top
Product cited in:

Xu, Liu, Zhang, Wang, Wang, Yang, Huo, Sun: "Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy." in: Neural regeneration research, Vol. 7, Issue 17, pp. 1318-24, 2015

Lu, Yuan, Ou, Cai, Wang, Sun, Zhang: "Autophagy and apoptosis during adult adipose-derived stromal cells differentiation into neuron-like cells in vitro." in: Neural regeneration research, Vol. 7, Issue 16, pp. 1205-12, 2015

Chen, Peng, Rowat, Gao, Zhang, Wang, Zhang, Wang, Qu: "The effect of concentration and duration of normobaric oxygen in reducing caspase-3 and -9 expression in a rat-model of focal cerebral ischaemia." in: Brain research, Vol. 1618, pp. 205-11, 2015

Ji, Yan, Li, Lai, Liu: "Therapeutic effects of intrathecal versus intravenous monosialoganglioside against bupivacaine-induced spinal neurotoxicity in rats." in: Biomedicine & pharmacotherapy = Biome?decine & pharmacothe?rapie, Vol. 69, pp. 311-6, 2015

Wu, Wang, Hou: "Alpha B-crystallin improved survival of retinal ganglion cells in a rat model of acute ocular hypertension." in: Neural regeneration research, Vol. 7, Issue 19, pp. 1493-7, 2015

Wang, Qu, Zhang, Zhang: "Testosterone suppresses ventricular remodeling and improves left ventricular function in rats following myocardial infarction." in: Experimental and therapeutic medicine, Vol. 9, Issue 4, pp. 1283-1291, 2015

Liu, Chen, Wang, Yang, Xue, Zhu: "Msi1 confers resistance to TRAIL by activating ERK in liver cancer cells." in: FEBS letters, Vol. 589, Issue 8, pp. 897-903, 2015

Peng, Liu, Wei, Lv, Wang, Xiong, Wang, Altaf, Wang, He, Wang, Qu: "P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation." in: International journal of molecular medicine, Vol. 35, Issue 5, pp. 1179-88, 2015

Zhang, Yan, Hu, Zhuang, Yu, Hang: "Increased Expression of NLRP3 Inflammasome in Wall of Ruptured and Unruptured Human Cerebral Aneurysms: Preliminary Results." in: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, Vol. 24, Issue 5, pp. 972-9, 2015

Huang, Huang, Xiao, Yang, Lin, Diao: "Kallistatin, a novel anti-angiogenesis agent, inhibits angiogenesis via inhibition of the NF-?B signaling pathway." in: Biomedicine & pharmacotherapy = Biome?decine & pharmacothe?rapie, Vol. 68, Issue 4, pp. 455-61, 2014

Mao, Song, Li, Lv, Zhao, Li, Feng, Chen: "8-hydroxy-2-(di-n-propylamino)tetralin intervenes with neural cell apoptosis following diffuse axonal injury." in: Neural regeneration research, Vol. 8, Issue 2, pp. 133-42, 2014

Dai, Li, Tang, Li, Xiao: "Colistin-induced nephrotoxicity in mice involves the mitochondrial, death receptor, and endoplasmic reticulum pathways." in: Antimicrobial agents and chemotherapy, Vol. 58, Issue 7, pp. 4075-85, 2014

Yuan, Sun, Ou, Wang, Zhang, Deng, Wu, Zhang: "Apoptosis is an obstacle to the differentiation of adipose-derived stromal cells into astrocytes." in: Neural regeneration research, Vol. 9, Issue 8, pp. 837-44, 2014

Chen, Dang, Wang, Tang, Liu, Wu: "The in vitro and in vivo anti-tumor effects of MTX-Fe3O 4-PLLA-PEG-PLLA microspheres prepared by suspension-enhanced dispersion by supercritical CO2." in: Science China. Life sciences, Vol. 57, Issue 7, pp. 698-709, 2014

Shu, Yu, Zhang, Liu, Wu, Zang, Yang, Zhou, Yin: "Expression of TRPV1 in cortical lesions from patients with tuberous sclerosis complex and focal cortical dysplasia type IIb." in: Brain & development, Vol. 35, Issue 3, pp. 252-60, 2013

Li, Peng, Song, Liang, Mei, Fang: "Electro-acupuncture combined with transcranial magnetic stimulation improves learning and memory function of rats with cerebral infarction by inhibiting neuron cell apoptosis." in: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, Vol. 32, Issue 5, pp. 746-9, 2012

Li, Li, Huang, Kan, Wang, Wu, Yin, Yao: "Dexamethasone and A???-?? accelerate learning and memory impairments due to elevate amyloid precursor protein expression and neuronal apoptosis in 12-month male rats." in: Behavioural brain research, Vol. 227, Issue 1, pp. 142-9, 2011

Fu, Zhao, Wu, Wu, Xu, Liu, Tong: "Therapeutic mechanisms of Tongmai Dasheng Tablet on tripterygium glycosides induced rat model for premature ovarian failure." in: Journal of ethnopharmacology, Vol. 139, Issue 1, pp. 26-33, 2011

Zhao, Wu, Wu, Jia, Gao, Yan, Wang: "Introduction of hypoxia-targeting p53 fusion protein for the selective therapy of non-small cell lung cancer." in: Cancer biology & therapy, Vol. 11, Issue 1, pp. 95-107, 2011

Ding, Zou, Li, Tian, Abdelalim, Du, She, Wang, Tan, Wang, Chen, Lv, Chang: "Study of histopathological and molecular changes of rat kidney under simulated weightlessness and resistance training protective effect." in: PLoS ONE, Vol. 6, Issue 5, pp. e20008, 2011

Images

Product Details anti-Caspase 1 Antibody Target Details Caspase 1 Application Details Handling References for anti-Caspase 1 antibody (ABIN5518669) back to top
Supplier Images
Western Blotting (WB) image for anti-Caspase 1 (CASP1) (AA 137-157), (N-Term) antibody (ABIN5518669) Anti-Caspase-1(P20) antibody, Western blotting Lane 1: Rat Brain Tissue Lysate Lane 2...