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Human SKP1 Protein expressed in Wheat germ - ABIN1320087
Mallampalli, Glasser, Coon, Chen: Calmodulin protects Aurora B on the midbody to regulate the fidelity of cytokinesis. in Cell cycle (Georgetown, Tex.) 2013
Segregation analysis revealed that variants c.475T>G in SKP1, c.671G>A in PROB1, and c.527G>A in IL17B in the 5q31.1-q35.3 linkage region, and c.850G>A in HKDC1 in the 10q22 locus completely segregated with the phenotype in the studied Keratoconus family
Both the F-box domain of Skp2 and Skp1-Skp2 domain motions displaying preferential conformational control can together facilitate polyubiquitination of a wide variety of substrates.
Skp1 is critical to lung cancer pathogenesis
Data show that epithelial-mesenchymal transition (EMT)-transcription factors can be dynamically degraded by an atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 (SPFFbxo45).
We discuss how these results can explain the rapid association of Cdc34 and Skp1-cullin-F-box ligase (SCF).
SKP1 variation modifies association between Parkinson's disease and ubiquitin-proteasome system-inhibiting pesticides
Studies indicate that in SCFs, Rbx1 serves as the RING-containing enzyme, Cul1 is the Cullin scaffold, and Skp1 is an adaptor, which serves to link the beta-TrCP F-box substrate-specific factor to the rest of the ligase.
Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex.
Skp1-Cul1-F-box ubiquitin ligase (SCF(betaTrCP))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry
Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism.
we determined that the phage-encoded GogB effector protein in Salmonella targets the host SCF E3 type ubiquitin ligase through an interaction with Skp1 and the human F-box only 22 (FBXO22) protein
This review suggested that SKP1 decreased in in sporadic Parkinson's disease.
phosphorylated NIPA is degraded in late mitosis in an APC/C(Cdh1)-dependent manner
SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein
These observations suggest that Skp1 plays an important role in stabilizing the conformation of these F-box proteins, which increases their expression levels and substrate-binding.
Skp1 binding prevented Fbxo7 from contacting CRM1.
Data demonstrate that PFKFB3 is essential for cell division and that it is regulated by APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP.
The siRNA-induced suppression of Skp2 increased p27 expression, decreased cellular proliferation, and increased apoptosis in human laryngeal carcinoma cells
These findings support a novel role for Hsp90-Sgt1 chaperones in ensuring the fidelity of Mis12 multiprotein complex assembly.
Skp1 and Fbg3 were co-expressed in E. coli. The plate-shaped crystals belonged to space group P2(1)2(1)2(1), with unit-cell parameters a = 34.1, b = 76.6, c = 193.9 A and one molecule per asymmetric unit.
Consistent with Skp1a functioning through regulation of Nmnat2, Skp1a knockdown fails to protect axons from Nmnat2 knockdown.
Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.
In this review, deficiency of SKP1A in SN4741 cells closely recapitulates cardinal features of the dopamine (DA) neuron pathology of human Parkinson's disease, such as decreased expression of DA phenotypic markers and cell cycle aberrations.
Skp1 is a potential modifier in sporadic Parkinson disease neurodegeneration
The SCF-complex gene expression has been characterized during bovine preimplantation development.
In vitro and in vivo protein-protein interaction assays show that NO enhances ASK1 binding to CUL1 and TIR1/AFB2, required for SCF(TIR1/AFB2) assembly.
Arabidopsis SKP-like proteins (ASKs) can significantly improve soluble expression of F-box proteins and maintain their bioactivity.
How ASK1 might regulate protein stability and further downstream gene expression
ABA induced the phosphorylation of three basic helix-loop-helix (bHLH) transcription factors, called AKSs (ABA-responsive kinase substrates; AKS1, AKS2, and AKS3), in Arabidopsis guard cells
ASK1 and ASK2, are required for Agrobacterium-mediated plant transformation.
ASK1 or ASK2 overexpression could rescue or partially rescue the Abscisic acid (ABA)insensitivity of abi5-1 mutants, respectively.
ASK1 is predominately expressed from leptotene to pachytene, and negatively regulates recombination in Arabidopsis.
Through the ASK1-mediated proteolysis pathway, ASK1 proteins showed pleiotropic functions including photomorphogenesis, circadian oscillation, post-translation process, stress-responses and cell expansion or elongation.
ASK1 is required for normal SYN1 distribution during meiotic prophase I and suggest that ask1 associated defects may be primarily related to SYN1 mislocalization.
These results raise the interesting possibility that ASK1 controls chromatin structure by targeting of either an early regulator of meiotic progression or possibly matrix attachment proteins for destruction.
study represents a thorough investigation showing that retroposition can play an important role in the evolution of a plant gene family whose members do not encode mobile elements
study evaluated the conformational stabilities of OCP1 and OCP2
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.
, RNA polymerase II elongation factor-like protein OCP2
, cyclin A/CDK2-associated p19
, cyclin A/CDK2-associated protein p19
, cyclin-A/CDK2-associated protein p19
, organ of Corti protein 2
, organ of Corti protein II
, transcription elongation factor B
, S-phase kinase-associated protein 1
, SCF complex component
, S-phase kinase-associated protein 1A
, S-phase kinase-associated protein 1A (p19A)