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Our data uncovered an important role of Erbin in regulating hepatocellular carcinoma (HCC (show FAM126A Proteins)) tumorigenesis through inactivating ERalpha (show ESR1 Proteins)-mediated tumor-suppressive signaling, suggesting a new strategy for tamoxifen therapy in HCC (show FAM126A Proteins) by targeting Erbin/ERalpha (show ESR1 Proteins) signaling axis.
STAT3 (show STAT3 Proteins) activation promotes ERBIN expression and negatively regulates TGF-beta (show TGFB1 Proteins) activity by the formation of a STAT3 (show STAT3 Proteins)-ERBIN-SMAD2 (show SMAD2 Proteins)/3 complex.
Erbin loss accelerates cell cycle though down-regulating p21 (show CDKN1A Proteins) and p27 (show PAK2 Proteins) expression. Erbin is a novel negative modulator of Akt1 (show AKT1 Proteins)-Skp2-p27 (show PAK2 Proteins) signaling pathway.
Erbin promotes tumourigenesis and tumour growth in colorectal cancer by stabilizing epidermal growth factor receptor (show EGFR Proteins)
Erbin is an ErbB2 (show ERBB2 Proteins) regulator for breast tumor formation and progression
analysis of the C-terminal ligand specificity of the erbin PDZ domain
Data suggest that Erbin can interact with Sema4C (show SEMA4C Proteins), and co-expression of Erbin blocks the process of Sema4C (show SEMA4C Proteins)-induced epithelial-mesenchymal transition.
Data reveal that Erbin is a negative regulator of AKT (show AKT1 Proteins) activation and suggest that Erbin may play a role in breast cancer progression.
DSG1 (show DSG1 Proteins) and Erbin cooperate to repress MAPK (show MAPK1 Proteins) signaling and promote keratinocyte differentiation.
These results unravel a critical role of c-Myb (show MYB Proteins) in promoting Erbin transcription in G2/M phase and also predict an unappreciated function of Erbin in cell cycle progression.
Overexpression of FHL2 (show FHL2 Proteins) alone had no effect on Erbin expression, but in the presence of MITF (show MITF Proteins), Erbin expression was decreased.
By degrading Erbin and Nrf2 (show NFE2L2 Proteins), Sag (show RNF7 Proteins) activates the Ras-Raf (show RAF1 Proteins) pathway and causes ROS (show ROS1 Proteins) accumulation to trigger autophagy and senescence
Results support that hyperglycemia may impair NRG1 (show NRG1 Proteins)/Erb (show ESR2 Proteins) B2 signaling by disrupting the balance between NRG1 (show NRG1 Proteins) isoforms, decreasing the expression of erbin and correspondingly activating the MAPK (show MAPK1 Proteins) pathway
Erbin is an inhibitor of pathological cardiac hypertrophy.
These observations demonstrate a crucial function for Erbin in AMPAR surface expression in cortical parvalbumin (show PVALB Proteins) positive interneurons
This study demonistrated that demonstrate that Erbin is required for remyelination of regenerated axons after injury, probably by regulating ErbB2 (show ERBB2 Proteins) and NRG1 (show NRG1 Proteins) levels, identifying a novel player in regulating remyelination.
preliminary characterization of its interaction with Smad3 (show SMAD3 Proteins)
erbin regulates MAP kinase (show MAPK1 Proteins) activation in Schwann cells and suggest that erbin links merlin (show NF2 Proteins) to both adherens junction protein complexes and the MAP kinase (show MAPK1 Proteins) signaling pathway.
Erbin is a regulator of Nod2-dependent NF-kappaB (show NFKB1 Proteins) signaling with a role in inflammatory responses
This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, protein LAP2
, erbb2 interacting protein
, ERBB2 interacting protein
, protein LAP2-like
, erbb2-interacting protein
, similar to Erbb2 interacting protein isoform 2