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anti-Human INSIG2 Antibodies:
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Cow (Bovine) Polyclonal INSIG2 Primary Antibody for WB - ABIN2778637
Li, Gruidl, Eschrich, McCarthy, Wang, Alexandrow, Yeatman: Insig2 is associated with colon tumorigenesis and inhibits Bax-mediated apoptosis. in International journal of cancer. Journal international du cancer 2008
Show all 2 Pubmed References
Human Polyclonal INSIG2 Primary Antibody for WB - ABIN4892461
Segatto, Di Giovanni, Marino, Pallottini: Analysis of the protein network of cholesterol homeostasis in different brain regions: an age and sex dependent perspective. in Journal of cellular physiology 2013
INSIG2 plays a role in weight gain and obesity during clozapine treatment
These results indicate that HIF-mediated induction of Insig-2 and degradation of HMGCR (show HMGCR Antibodies) are physiologically relevant events that guard against wasteful oxygen consumption and inappropriate cell growth during hypoxia.
There may be a connection between INSIG2 expression and metastatic dissemination of colorectal cancer without any effect on tumorigenesis.
Insulin (show INS Antibodies) resistance in obese boys leads to up-regulation of INSIG2 gene expression as well as to down-regulation of PFKFB1 (show PFKFB1 Antibodies), PFKFB3 (show PFKFB3 Antibodies), and HK2 (show HK2 Antibodies) genes in the blood cells as compared to obese patients with normal insulin (show INS Antibodies) sensitivity.
Results confirmed that genetic variation in INSIG2 is associated with both overweight and LDL in non-Hispanic white children.
This study suggests that the G allele in the INSIG2 single nucleotide polymorphism rs7566605 is more relevant for changes in intramuscular adipose tissue following training than for the amount of subcutaneous fat.
INSIG2 is involved in adipogenesis and MC4R (show MC4R Antibodies) effects hormonal appetite control in response to the amount of adipose tissue.
The results provided evidence for identifying genetic factors of nonalcoholic fatty liver disease (NAFLD (show TSC2 Antibodies)) and may be useful for risk assessment and personalized medicine of NAFLD (show TSC2 Antibodies).
The INSIG2 rs7566605 SNP may not play a role in the development of obesity-related metabolic traits in Malaysian Malays.
identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect.
FASN (show FASN Antibodies) gene is a promising marker for subcutaneous fat tissue accumulation, while INSIG2 is a promising marker for FA composition
INSIG2 is a negative regulator of SREBP, and acute glucocorticoid treatment decreased active SREBP during refeeding or in livers of Ob/Ob mice, both systems of elevated SREBP-1c (show SREBF1 Antibodies)-driven lipogenesis.
Data show that REV-ERBalpha (show NR1D1 Antibodies) participates in the circadian modulation of SREBP activity, and the expression of SREBP target genes involved in cholesterol and lipid metabolism via the cyclic transcription of Insig2.
Liver-specific mRNA for Insig-2 down-regulated by insulin (show INS Antibodies): implications for fatty acid synthesis.
a vitamin D response element in the murine Insig-2 promoter may have a role in the differentiation of 3T3-L1 preadipocytes
Insig2 identified as a strong candidate susceptibility gene for total plasma cholesterol levelsin inbred mice strains
Treatment of pregnant mice with the HMG-CoA reductase (show HMGCR Antibodies) inhibitor lovastatin reduced sterol synthesis in Insig2-knockout embryos and reduced the pre-cholesterol intermediates ameliorating the clefting.
A critical gene involved in cholesterol homeostasis, Insig-2, was induced when mice or cultured cells were treated with FXRalpha (show NR1H4 Antibodies) agonists or infected with constitutively active FXRalpha (show NR1H4 Antibodies).
Peroxisome deficiency causes a complex phenotype because of hepatic SREBP-1c (show SREBF1 Antibodies),-2/Insig-2a,b dysregulation associated with endoplasmic reticulum stress
Silibinin inhibits adipocyte differentiation through a potential up-regulation of insig-1 (show INSIG1 Antibodies) and insig-2 at an early phase in adipocyte differentiation.
The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.
insulin-induced gene 2 protein
, insulin-induced gene 2 protein-like
, insulin induced gene 2
, INSIG2 membrane protein
, insulin induced protein 2
, insulin-induced membrane protein 2
, INSIG-2 membrane protein
, Insulin-induced gene 2 protein