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Human IL7 Protein expressed in Escherichia coli (E. coli) - ABIN1305105
Goodwin, Lupton, Schmierer, Hjerrild, Jerzy, Clevenger, Gillis, Cosman, Namen: Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells. in Proceedings of the National Academy of Sciences of the United States of America 1989
Show all 3 Pubmed References
Mouse (Murine) IL7 Protein expressed in Escherichia coli (E. coli) - ABIN1888631
Chari, Winandy: Ikaros regulates Notch target gene expression in developing thymocytes. in Journal of immunology (Baltimore, Md. : 1950) 2008
Human IL7 Protein expressed in Escherichia coli (E. coli) - ABIN1888605
Staron, Yang, Liu, Li, Shen, Zúñiga-Pflücker, Aguila, Goldschneider, Li: gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis. in Blood 2010
increased IL-7 protein production in situ (lung tissue) from non-human primates who received rBCG vaccination, which was associated with increased survival.
The constitutively signaling C7R system developed here delivers potent IL7 stimulation to CAR T cells, increasing their persistence and antitumor activity against multiple preclinical tumor models, supporting its clinical development
we demonstrated that Imatinib mesylate (IM)impaired T cell survival through the inhibition of IL-7 and STAT5 (show STAT5A Proteins)-p but not TCR signaling which remained unaffected during IM therapy. Thus, off-target inhibitory effects of IM on IL-7 and STAT5 (show STAT5A Proteins)-p explain how T cell lymphopenia occurs in patients treated with IM.
In this study, authors compared the concentrations of IL-15 (show IL15 Proteins) and IL-7 in the plasma of MDS (show PAFAH1B1 Proteins) patients (n = 20) compared with that in the plasma of healthy controls (n = 20).
Data strongly implicate IL-7 in the thymus-independent long-term survival of functional naive-Tregs.
the critical role played by IL-7 and IL-15 in T cell homeostasis and how these cytokines could be used to improve immune reconstitution after allogeneic SCT.
IL-7/IL-7R signaling pathway plays a possible role in recurrent pregnancy loss by upregulating Th17 immunity while downregulating Treg immunity.
IL-7 inhibits the osteogenic differentiation of Periodontal ligament stem cells probably via inactivation of mitogen-activated protein kinase (show MAPK1 Proteins) (MAPK (show MAPK1 Proteins)) signaling pathway.
this study shows that IL-7 restores T Lymphocyte immunometabolic failure in septic shock patients through mTOR (show FRAP1 Proteins) activation
In CRC (show CALR Proteins), IL-7 was higher in patients with lymph node and distant metastases and with tumors located in right colon. In adenomas, IL-7 elevation was associated exclusively with villous growth pattern, while in IBD, circulating IL-7 reflected clinical activity of Crohn's disease and ulcerative colitis.
Tuberculosis patients had lower soluble IL-7R and higher IL-7 plasma concentrations as compared to healthy contacts.
This finding warrants future development of IL-21 (show IL21 Proteins) and IL-7 co-expressing whole-cell cancer vaccines and their relevant combinatorial regimens.
both Flt3 ligand (FL (show FLT3LG Proteins)) and IL-7 regulate B-cell commitment in a permissive manner: FL by inducing proliferation of Ly6D (show LY6D Proteins)(+)CD135 (show FLT3 Proteins)(+)CD127 (show IL7R Proteins)(+)CD19 (show CD19 Proteins)(-) progenitors and IL-7 by providing survival signals to these progenitors
the in vivo biological role of m(6)A modification in T-cell-mediated pathogenesis and reveals a novel mechanism of T cell homeostasis and Il-7 signal-dependent induction of mRNA degradation
Our new compelling findings have established the critical roles of both IL-7 and IL-15 (show IL15 Proteins) in the maintenance of memory Th17 cells, and the previously undescribed therapeutic advantages of targeting IL-7 and IL-15 (show IL15 Proteins) further support a promising clinical translation in Th17 cell-mediated autoimmune and inflammatory disorders.
Taken together, these data suggest that CCR7 (show CCR7 Proteins) biases memory CD8 (show CD8A Proteins) T cells toward IL-7-dependent niches over IL-15 (show IL15 Proteins)-dependent niches, which provides insight into the homeostatic regulation of different memory T-cell subsets.
this study shows that IL-7 homeostasis is achieved through consumption by multiple subsets of innate and adaptive immune cells
lymphatic vessel expansion occurs in two distinct phases; the first wave of expansion is dependent on IL-7; the second phase, responsible for leukocyte exit from the glands, is regulated by lymphotoxin (show LTB Proteins) (LT)betaR signaling
DNM2 (show DNM2 Proteins) mutations cooperate with Lmo2 (show LMO2 Proteins) T-cell oncogenes by enhancing IL-7 signalling.
IL-7 responsiveness in RTE is designed to maximize survival at the expense of reduced proliferation, consistent with RTE serving as a subpopulation of T cells rich in diversity but not in frequency.
The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.